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Thierry VOISIN - Publications


MAINTAIN - MAintain Functions and INTrinsec capacities with Aging : Preventive and Personalized INterventional Research

Equipe constitutive du CERPOP, UMR1295, unité mixte INSERM - Université Toulouse III Paul Sabatier
Thierry VOISIN •  chercheur


  1. Aggarwal G, Morley JE, Vellas B, Nguyen AD, Butler AA; MAPT/DSA Group (Voisin T collaborator) . Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults. Geroscience. 2023 May 26. doi: 10.1007/s11357-023-00824-3. Epub ahead of print.
  2. Bencivenga L, Strumia M, Rolland Y, Martinez L, Cestac P, Guyonnet S, Andrieu S, Parini A, Lucas A, Vellas B, De Souto Barreto P, Rouch L; MAPT/D. S. A. group (Voisin T collaborator) . Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability. Geroscience. 2023 Apr;45(2):797-809. doi: 10.1007/s11357-022-00697-y.
  3. Gonzalez-Bautista E, de Souto Barreto P, Salinas-Rodriguez A, Manrique-Espinoza B, Sourdet S, Rolland Y, Rodríguez-Mañas L, Andrieu S, Vellas B; MAPT/DSA Group (Voisin T collaborator) . Development and Validation of a Cutoff for the Chair Stand Test as a Screening for Mobility Impairment in the Context of the Integrated Care for Older People Program. J Gerontol A Biol Sci Med Sci. 2023 Jan 26;78(1):104-110. doi: 10.1093/gerona/glac055.
  4. Grasset L, Planche V, Bouteloup V, Azouani C, Dubois B, Blanc F, Paquet C, David R, Belin C, Jonveaux T, Julian A, Pariente J, Mangin JF, Chêne G, Dufouil C; Memento Cohort Study Group (Voisin T collaborator) . Physical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort. Alzheimers Dement. 2023 Jul 8. doi: 10.1002/alz.13360. Epub ahead of print.
  5. Giudici KV, de Souto Barreto P, Guyonnet S, Morley JE, Nguyen AD, Aggarwal G, Parini A, Li Y, Bateman RJ, Vellas B; MAPT/DSA Group (Voisin T collaborator) . TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study. J Gerontol A Biol Sci Med Sci. 2023 Mar 30;78(4):569-578. doi: 10.1093/gerona/glac244.
  6. Perus L, Mangin JF, Deverdun J, Gutierrez LA, Gourieux E, Fischer C, Van Dokkum LEH, Manesco C, Busto G, Guyonnet S, Vellas B, Gabelle A, Le Bars E; MAPT/DSA group (Voisin T collaborator) . Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study. Front Aging Neurosci. 2023 Jan 10;14:971220. doi: 10.3389/fnagi.2022.971220.
  7. Raffin J, Rolland Y, Parini A, Lucas A, Guyonnet S, Vellas B, de Souto Barreto P; MAPT/DSA Group (Voisin T collaborator) . Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis. J Cachexia Sarcopenia Muscle. 2023 Jan 20;14(2):771–80. doi: 10.1002/jcsm.13152. Epub ahead of print.


  1. He L, de Souto Barreto P, Sánchez Sánchez JL, Rolland Y, Guyonnet S, Parini A, Lucas A, Vellas B; MAPT/DSA Group (Voisin T collaborator). Prospective Associations of Plasma Growth Differentiation Factor 15 With Physical Performance and Cognitive Functions in Older Adults. J Gerontol A Biol Sci Med Sci. 2022 Dec 29;77(12):2420-2428. doi: 10.1093/gerona/glac020.
  2. Lu WH, Giudici KV, Morley JE, Guyonnet S, Parini A, Aggarwal G, Nguyen AD, Li Y, Bateman RJ, Vellas B, de Souto Barreto P; MAPT/DSA Group (Voisin T collaborator). Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults. Geroscience. 2022 Jun;44(3):1489-1503. doi: 10.1007/s11357-022-00554-y.
  3. Molet-Benhamou L, Giudici KV, de Souto Barreto P, Cantet C, Rolland Y; MAPT/DSA group  (Voisin T collaborator) . Association between urate-lowering therapies and cognitive decline in community-dwelling older adults. Sci Rep. 2022 Sep 12;12(1):15299. doi: 10.1038/s41598-022-17808-6.
  4. Pagès A, Costa N, Mounié M, Cestac P, De Souto Barreto P, Rolland Y, Vellas B, Molinier L, Juillard-Condat B; MAPT/DSA Group (Voisin T collaborator). Healthcare Costs Associated with Potentially Inappropriate Medication Prescribing Detected by Computer Algorithm Among Older Patients. Drugs Aging. 2022 May;39(5):367-375. doi: 10.1007/s40266-022-00938-x.
  5. Raffin J, Angioni D, Giudici KV, Valet P, Aggarwal G, Nguyen AD, Morley JE, Guyonnet S, Rolland Y, Vellas B, de Souto Barreto P; MAPT/DSA Group (Voisin T collaborator). Physical Activity, Body Mass Index, and Blood Progranulin in Older Adults: Cross-Sectional Associations in the MAPT Study. J Gerontol A Biol Sci Med Sci. 2022 Jun 1;77(6):1141-1149. doi: 10.1093/gerona/glac018.
  6. Sanchez-Sanchez JL, Giudici KV, Guyonnet S, Delrieu J, Li Y, Bateman RJ, Parini A, Vellas B, de Souto Barreto P; MAPT/DSA Group (Voisin T collaborator). Plasma MCP-1 and changes on cognitive function in community-dwelling older adults. Alzheimers Res Ther. 2022 Jan 7;14(1):5. doi: 10.1186/s13195-021-00940-2.


  1. Frison E, Proust-Lima C, Mangin JF, Habert MO, Bombois S, Ousset PJ, Pasquier F, Hanon O, Paquet C, Gabelle A, Ceccaldi M, Annweiler C, Krolak-Salmon P, Béjot Y, Belin C, Wallon D, Sauvee M, Beaufils E, Bourdel-Marchasson I, Jalenques I, Chupin M, Chêne G, Dufouil C; MEMENTO Cohort Study Group (Voisin T collaborator). Diabetes Mellitus and Cognition: Pathway Analysis in the MEMENTO Cohort. Neurology. 2021 Aug 24;97(8):e836-e848. doi: 10.1212/WNL.0000000000012440.
  2. Gallini A, Renoux A, Siep S, Roustan A, Voisin T, Escudier G, Muller P, Gardette V. Clustering 5-Year Multidimensional Health Care Trajectory Patterns in Alzheimer's Disease and Related Syndromes. J Am Med Dir Assoc. 2021 Jul;22(7):1525-1534.e3 . doi: 10.1016/j.jamda.2021.01.085.
  3. He L, Morley JE, Aggarwal G, Nguyen AD, Vellas B, de Souto Barreto P; MAPT/DSA Group (Voisin T collaborator). Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults. Sci Rep. 2021 Jun 28;11(1):13394. doi: 10.1038/s41598-021-91038-0.
  4. Lu WH, de Souto Barreto P, Rolland Y, Bouyahia A, Fischer C, Mangin JF, Giudici KV, Vellas B; MAPT/DSA Group (Voisin T collaborator). Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study. J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):e361-e369. doi: 10.1093/gerona/glaa296.
  5. Raffin J, Rolland Y, Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, Vellas B, Barreto PS; MAPT/DSA Group (Voisin T collaborator). Associations Between Physical Activity, Blood-Based Biomarkers of Neurodegeneration, and Cognition in Healthy Older Adults: The MAPT Study. J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):1382-1390. doi: 10.1093/gerona/glab094.
  6. Takano E, Maltais M, Kondo I, Rolland Y; MAPT/DSA group (Voisin T collaborator). Bidirectional relationship between depressive symptoms and physical performance in community-dwelling older people with subjective memory complaints. Eur Geriatr Med. 2021 Oct;12(5):973-980. doi: 10.1007/s41999-021-00473-9.


  • Delrieu J, Voisin T, Saint-Aubert L, Carrie I, Cantet C, Vellas B, Payoux P, Andrieu S. The impact of a multi-domain intervention on cerebral glucose metabolism: analysis from the randomized ancillary FDG PET MAPT trial. Alzheimers Res Ther. 2020 Oct 19;12(1):134. doi: 10.1186/s13195-020-00683-6.
  • Maltais M, de Souto Barreto P, Perus L, Mangin JF, Grigis A, Chupin M, Bouyahia A, Gabelle A, Delrieux J, Rolland Y, Vellas B; Multidomain Alzheimer Preventive Trial/Data Sharing Alzheimer (MAPT/DSA) Study Group (Voisin T collaborator). Prospective Associations Between Diffusion Tensor Imaging Parameters and Frailty in Older Adults. J Am Geriatr Soc. 2020;68(5):1050-1055. doi:10.1111/jgs.16343.
  • Pagès A, Roland C, Qassemi S, Abdeljalil AB, Houles M, Romain M, Toulza O, Belloc A, McCambridge C, Voisin T, Cestac P, Juillard-Condat B; PharMoG study group. Impact of a Pharmacist-included Mobile Geriatrics team intervention on potentially inappropriate drug prescribing: protocol for a prospective feasibility study (PharMoG study). BMJ Open. 2020 Dec 2;10(12):e040917. doi: 10.1136/bmjopen-2020-040917.
  • Soriano G, De Souto Barreto P, Virecoulon Giudici K, Cantet C, Guyonnet S, Vellas B, Rolland Y, Andrieu S; MAPT DSA Study Group (Voisin T collaborator). Meal-related difficulties and weight loss in older people: Longitudinal data from MAPT study.  Clin Nutr. 2020 Nov;39(11):3483-3488. doi: 10.1016/j.clnu.2020.03.011. Epub ahead of print.


  • Coley N, Ngandu T, Lehtisalo J, Soininen H, Vellas B, Richard E, Kivipelto M, Andrieu S; HATICE, FINGER, and MAPT/DSA groups (Voisin T collaborator). Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials. Alzheimers Dement. 2019;15(6):729-74 doi:10.1016/j.jalz.2019.03.005.
  • Couvineau A, Voisin T, Nicole P, Gratio V, Abad C, Tan YV. Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases. Front Endocrinol (Lausanne). 2019;10:709. Published 2019 Oct 2 doi:10.3389/fendo.2019.00709.
  • Gabelle A, Jaussent I, Bouallègue FB, Lehmann S, Lopez R, Barateau L, Grasselli C, Pesenti C, de Verbizier D, Béziat S, Mariano-Goulart D, Carlander B, Dauvilliers Y; Alzheimer's Disease Neuroimaging Initiative; Multi-Domain Intervention Alzheimer's Prevention Trial study groups (Voisin T collaborator). Reduced brain amyloid burden in elderly patients with narcolepsy type 1. Ann Neurol. 2019;85(1):74-8 doi:10.1002/ana.25373.
  • Piau A, Krams T, Voisin T, Lepage B, Nourhashemi F. Use of a robotic walking aid in rehabilitation to reduce fear of falling is feasible and acceptable from the end user's perspective: A randomised comparative study. Maturitas. 2019;120:40-46. doi:10.1016/j.maturitas.2018.11.008.

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