MAINTAIN - MAintain Functions and INTrinsec capacities with Aging : Preventive and Personalized INterventional Research

Equipe constitutive du CERPOP, UMR1295, unité mixte INSERM - Université Toulouse III Paul Sabatier


  • Lu WH, Giudici KV, Rolland Y, Guyonnet S, Li Y, Bateman RJ, de Souto Barreto P, Vellas B. Prospective Associations between Plasma Amyloid-Beta 42/40 and Frailty in Community-Dwelling Older Adults. J Prev Alzheimers Dis. 2021;8(1):41-47. doi: 10.14283/jpad.2020.60.


  • Guerville F, De Souto Barreto P, Ader I, Andrieu S, Casteilla L, Dray C, Fazilleau N, Guyonnet S, Langin D, Liblau R, Parini A, Valet P, Vergnolle N, Rolland Y, Vellas B. Revisiting the Hallmarks of Aging to Identify Markers of Biological Age. J Prev Alzheimers Dis. 2020;7(1):56-64. doi:10.14283/jpad.2019.50.
  • Giudici KV, de Souto Barreto P, Guyonnet S, Li Y, Bateman RJ, Vellas B; MAPT/DSA Group. Assessment of Plasma Amyloid-β42/40 and Cognitive Decline Among Community-Dwelling Older Adults. JAMA Netw Open. 2020 Dec 1;3(12):e2028634.  doi: 10.1001/jamanetworkopen.2020.28634.
  • He L, de Souto Barreto P, Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, Vellas B; MAPT/DSA Group (Guyonnet S, Vellas B collaborators). Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults. Alzheimers Res Ther. 2020 Oct 8;12(1):128. doi: 10.1186/s13195-020-00697-0.
  • Maltais M, de Souto Barreto P, Perus L, Mangin JF, Grigis A, Chupin M, Bouyahia A, Gabelle A, Delrieux J, Rolland Y, Vellas B; Multidomain Alzheimer Preventive Trial/Data Sharing Alzheimer (MAPT/DSA) Study Group (Guyonnet S collaborator). Prospective Associations Between Diffusion Tensor Imaging Parameters and Frailty in Older Adults. J Am Geriatr Soc. 2020 May;68(5):1050-1055. doi: 10.1111/jgs.16343.
  • Maquet J, Lafaurie M, Sommet A, Moulis G; Covid-Clinic-Toul investigators group, Alvarez M, Amar J, Attal M, Balardy L, Balen F, Beyne-Rauzy O, Bouali O, Bounes F, Bureau C, Buscail L, Calviere L, Charpentier S, Chollet F, Claudet I, Constantin A, Debard A, Delavigne K, Delobel P, Delrieu J, Didier A, Faruch M, Fourcade O, Georges B, Grunenwald E, Guyonnet S, Hanaire H, Hein C, Kamar N, Lairez O, Mansat P, Martin-Blondel G, Minville V, Pariente J, Paul C, Payoux P, Pugnet G, Piel-Julian ML, Recher C, Rolland Y, Ruyssen-Witrand A, Sabatier J, Sailler L, Salles JP, Sans N, Secher M, Sevely A, Silva S, Thalamas C, Toulza O.. Thrombocytopenia is independently associated with poor outcome in patients hospitalized for COVID-19 [published online ahead of print, 2020 Jun 17]. Br J Haematol. 2020;10.1111/bjh.16950. doi: 10.1111/bjh.16950.
  • Soriano G, De Souto Barreto P, Virecoulon Giudici K, Cantet C, Guyonnet S, Vellas B, Rolland Y, Andrieu S; MAPT DSA Study Group. Meal-related difficulties and weight loss in older people: Longitudinal data from MAPT study. Clin Nutr. 2020 Mar 16:S0261-5614(20)30114-X. doi: 10.1016/j.clnu.2020.03.011.
  • Takeda C, Guyonnet S, Ousset PJ, Soto M, Vellas B. Toulouse Alzheimer's Clinical Research Center Recovery after the COVID-19 Crisis: Telemedicine an Innovative Solution for Clinical Research during the Coronavirus Pandemic. J Prev Alzheimers Dis. 2020;7(4):301-304. doi: 10.14283/jpad.2020.32.
  • Takeda C, Guyonnet S, Sumi Y, Vellas B, Araujo de Carvalho I. Integrated Care for Older People and the Implementation in the INSPIRE Care Cohort. J Prev Alzheimers Dis. 2020;7(2):70-74. doi: 10.14283/jpad.2020.8.


  • Bowman GL, Dodge HH, Guyonnet S, Zhou N, Donohue J, Bichsel A, Schmitt J, Hooper C, Bartfai T, Andrieu S, Vellas B; MAPT/DSA Study Group. A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial. Alzheimers Dement (N Y). 2019 Dec 28;5:953-963. doi: 10.1016/j.trci.2019.11.004. Erratum in: Alzheimers Dement (N Y). 2020 Jul 14;6(1):e12042.
  • Coley N, Ngandu T, Lehtisalo J, Soininen H, Vellas B, Richard E, Kivipelto M, Andrieu S; HATICE, FINGER, and MAPT/DSA groups (Guyonnet S collaborator). Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials Alzheimers Dement. 2019;15(6):729–741. doi:10.1016/j.jalz.2019.03.005.
  • Fougère B, Boulanger E, Nourhashémi F, Guyonnet S, Cesari M. Retraction to Chronic Inflammation: Accelerator of Biological Aging [retraction of: J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1218-1225]. J Gerontol A Biol Sci Med Sci. 2019;74(3):431. doi:10.1093/gerona/gly284.
  • Gabelle A, Jaussent I, Bouallègue FB, Lehmann S, Lopez R, Barateau L, Grasselli C, Pesenti C, de Verbizier D, Béziat S, Mariano-Goulart D, Carlander B, Dauvilliers Y; Alzheimer's Disease Neuroimaging Initiative; Multi-Domain Intervention Alzheimer's Prevention Trial study groups (Guyonnet S collaborator). Reduced brain amyloid burden in elderly patients with narcolepsy type 1. Ann Neurol. 2019 Jan;85(1):74-83. doi: 10.1002/ana.25373.
  • Giudici KV, Guyonnet S, Rolland Y, Vellas B, de Souto Barreto P, Nourhashemi F; MAPT/DSA Group. Body Weight Variation Patterns as Predictors of Cognitive Decline over a 5 Year Follow-Up among Community-Dwelling Elderly (MAPT Study). Nutrients. 2019 Jun 18;11(6):1371. doi: 10.3390/nu11061371.
  • Rolland Y, Barreto PS, Maltais M, Guyonnet S, Cantet C, Andrieu S, Vellas B. Effect of Long-Term Omega 3 Polyunsaturated Fatty Acid Supplementation with or without Multidomain Lifestyle Intervention on Muscle Strength in Older Adults: Secondary Analysis of the Multidomain Alzheimer Preventive Trial (MAPT). Nutrients. 2019 Aug 16;11(8). pii: E1931. doi: 10.3390/nu11061371.
  • Soriano G, De Barreto PS, Rolland Y, Plessz M, Goisser S, Guyonnet S, Fougère B, Vellas B, Andrieu S, Sourdet S; Groupe DSA.  Ready-meal consumption in older people: association with obesity and dietary intake. MAPT.Aging Clin Exp Res. 2019 Jun;31(6):855-861. doi: 10.1007/s40520-018-1043-5.