MAINTAIN - MAintain Functions and INTrinsec capacities with Aging :
Preventive and personalized INterventional Research

Equipe constitutive du CERPOP, UMR1295, unité mixte INSERM - Université Toulouse III Paul Sabatier
Sophie GUYONNET •  chercheure

2024

  1. Bencivenga L, Strumia M, Rolland Y, Guyonnet S, Parini A, Cestac P, Andrieu S, Souto Barreto P, Rouch L; MAPT/DSA group. Visit-to-visit blood pressure variability is associated with intrinsic capacity decline: Results from the MAPT Study. Eur J Intern Med. 2024 Mar 18:S0953-6205(24)00097-9. doi: 10.1016/j.ejim.2024.03.00 Epub ahead of print.
  2. da Silva JA, Martinez LO, Rolland Y, Najib S, Croyal M, Perret B, Jabrane-Ferrat N, El Costa H, Guyonnet S, Vellas B, de Souto Barreto P; MAPT/DSA group. Plasma Level of ATPase Inhibitory Factor 1 and Intrinsic Capacity in Community-Dwelling Older Adults: Prospective Data From the MAPT Study. J Gerontol A Biol Sci Med Sci. 2024 Jan 1;79(1):glad142. doi: 10.1093/gerona/glad142.
  3. Coley N, Zetterberg H, Cantet C, Guyonnet S, Ashton NJ, Vellas B, Blennow K, Andrieu S; MAPT study group (Abellan Van Kan G, Delrieu J. collaborators). Plasma p-tau181 as an outcome and predictor of multidomain intervention effects: a secondary analysis of a randomised, controlled, dementia prevention trial. Lancet Healthy Longev. 2024. 5(2):e120-e130. doi: 10.1016/S2666-7568(23)00255-6.
  4. Giudici KV, de Souto Barreto P, Guyonnet S, Beard JR, Takeda C, Cantet C, Andrieu S, Vellas B; IHU HealthAge INSPIRE Platform Group (Coley N collaborator). Predictive Capacity of the Integrated Care for Older People Screening Tool for Intrinsic Capacity Impairments: Results From the INSPIRE-T Cohort. J Gerontol A Biol Sci Med Sci. 2024. 79(7):glae112. doi: 10.1093/gerona/glae112.
  5. Lengelé L, Rolland Y, Martinez LO, Guyonnet S, Parini A, Lucas A, Vellas B, Barreto PS; MAPT/DSA Group (Coley N, Delrieu J collaborators). Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study. J Gerontol A Biol Sci Med Sci. 2024. 79(1):glad236. doi: 10.1093/gerona/glad236.
  6. Raffin J, Rolland Y, Aubertin-Leheudre M, Aragoni da Silva J, Guyonnet S, Pillard F, Vellas B, de Souto Barreto P; INSPIRE group. Cross-sectional interactive associations of physical activity and sedentary behaviour with physical capacity across adulthood. J Cachexia Sarcopenia Muscle. 2024. 15(3):1134-1145. doi: 10.1002/jcsm.13457.
  7. Raffin J, Rolland Y, Genoux A, Combes G, Croyal M, Perret B, Guyonnet S, Vellas B, Martinez LO, de Souto Barreto P; MAPT/DSA Group. Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults. J Sport Health Sci. 2024. 13(3):409-418. doi: 10.1016/j.jshs.2023.09.009.
  8. Tremblay-Franco M, Canlet C, Carriere A, Nakhle J, Galinier A, Portais JC, Yart A, Dray C, Lu WH, Bertrand Michel J, Guyonnet S, Rolland Y, Vellas B, Delrieu J, Barreto PS, Pénicaud L, Casteilla L, Ader I; MAPT/DSA Group. Integrative Multimodal Metabolomics to Early Predict Cognitive Decline Among Amyloid Positive Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2024. 79(5):glae077. doi: 10.1093/gerona/glae077.
  9. Aggarwal G, Morley JE, Vellas B, Nguyen AD, Butler AA (Delrieu J, Coley N, Guyonnet S  collaborators) ; MAPT/DSA Group. Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults. Geroscience. 2024. 46(1):897-91 doi: 10.1007/s11357-023-00824-3.

2023

  1. Aggarwal G, Morley JE, Vellas B, Nguyen AD, Butler AA; MAPT/DSA Group (Guyonnet S collaborator). Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults. Geroscience. 2023 May 26. doi: 10.1007/s11357-023-00824-3. Epub ahead of print.
  2. Bencivenga L, Strumia M, Rolland Y, Martinez L, Cestac P, Guyonnet S, Andrieu S, Parini A, Lucas A, Vellas B, De Souto Barreto P, Rouch L; MAPT/D. S. A. group. Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability. Geroscience. 2023 Apr;45(2):797-809. doi: 10.1007/s11357-022-00697-y.
  3. Boureau AS, Guyomarch B, Gourdy P, Allix I, Annweiler C, Cervantes N, Chapelet G, Delabrière I, Guyonnet S, Litke R, Paccalin M, Penfornis A, Saulnier PJ, Wargny M, Hadjadj S, de Decker L, Cariou B. Nocturnal hypoglycemia is underdiagnosed in older people with insulin-treated type 2 diabetes: The HYPOAGE observational study. J Am Geriatr Soc. 2023 Jul;71(7):2107-2119. doi: 10.1111/jgs.18341.
  4. Grande de França NA, Rolland Y, Guyonnet S, de Souto Barreto P. The role of dietary strategies in the modulation of hallmarks of aging. Ageing Res Rev. 2023 Jun;87:101908. doi: 10.1016/j.arr.2023.101908.
  5. Giudici KV, de Souto Barreto P, Guyonnet S, Morley JE, Nguyen AD, Aggarwal G, Parini A, Li Y, Bateman RJ, Vellas B; MAPT/DSA Group. TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study. J Gerontol A Biol Sci Med Sci. 2023 Mar 30;78(4):569-578. doi: 10.1093/gerona/glac244.
  6. Lu WH, Gonzalez-Bautista E, Guyonnet S, Lucas A, Parini A, Walston JD, Vellas B, de Souto Barreto P; MAPT/DSA Group. Plasma inflammation-related biomarkers are associated with intrinsic capacity in community-dwelling older adults. J Cachexia Sarcopenia Muscle. 2023 Apr;14(2):930-939. doi: 10.1002/jcsm.13163.
  7. Pires Da Silva J, Wargny M, Raffin J, Croyal M, Duparc T, Combes G, Genoux A, Perret B, Vellas B, Guyonnet S, Thalamas C, Langin D, Moro C, Viguerie N, Rolland Y, Barreto PS, Cariou B, Martinez LO; MAPT/DSA Group. Plasma level of ATPase inhibitory factor 1 (IF1) is associated with type 2 diabetes risk in humans: A prospective cohort study. Diabetes Metab. 2023 Jan;49(1):101391. doi: 10.1016/j.diabet.2022.101391.
  8. Raffin J, Rolland Y, Parini A, Lucas A, Guyonnet S, Vellas B, de Souto Barreto P; MAPT/DSA Group. Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis. J Cachexia Sarcopenia Muscle. 2023 Jan 20;14(2):771–80. doi: 10.1002/jcsm.13152. Epub ahead of print.
  9. Silva JAD, Martinez LO, Rolland Y, Najib S, Croyal M, Perret B, Jabrane-Ferrat N, El Costa H, Guyonnet S, Vellas B, Barreto PS; MAPT/DSA group. Plasma Level of ATPase Inhibitory Factor 1 (IF1) and intrinsic capacity in community-dwelling older adults: Prospective data from the MAPT Study. J Gerontol A Biol Sci Med Sci. 2023 Jun 6:glad142. doi: 10.1093/gerona/glad142. Epub ahead of print.
2022
  1. Angioni D, Lu WH, Sourdet S, Macaron T, Takeda C, Guyonnet S, Mangin JF, Rolland Y, de Souto Barreto P, Vellas B. Biomarkers of Age-Related Frailty and Frailty Related to Diseases: An Exploratory, Cross-Sectional Analysis from the MAPT Study. J Nutr Health Aging. 2022;26(6):545-551. doi: 10.1007/s12603-022-1793-9.
  2. Bernabei R, Landi F, Calvani R, Cesari M, Del Signore S, Anker SD, Bejuit R, Bordes P, Cherubini A, Cruz-Jentoft AJ, Di Bari M, Friede T, Gorostiaga Ayestarán C, Goyeau H, Jónsson PV, Kashiwa M, Lattanzio F, Maggio M, Mariotti L, Miller RR, Rodriguez-Mañas L, Roller-Wirnsberger R, Rýznarová I, Scholpp J, Schols AMWJ, Sieber CC, Sinclair AJ, Skalska A, Strandberg T, Tchalla A, Topinková E, Tosato M, Vellas B, von Haehling S, Pahor M, Roubenoff R, Marzetti E; SPRINTT consortium (Guyonnet S collaborator). Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project). BMJ. 2022 May 11;377:e068788. doi: 10.1136/bmj-2021-068788.
  3. Bischoff-Ferrari HA, Freystätter G, Vellas B, Dawson-Hughes B, Kressig RW, Kanis JA, Willett WC, Manson JE, Rizzoli R, Theiler R, Hofbauer LC, Armbrecht G, da Silva JAP, Blauth M, de Godoi Rezende Costa Molino C, Lang W, Siebert U, Egli A, Orav EJ, Wieczorek M; DO-HEALTH Research Group (Guyonnet S collaborator). Effects of vitamin D, omega-3 fatty acids and a simple home strength exercise program on fall prevention: the DO-HEALTH randomized clinical trial. Am J Clin Nutr. 2022 May 1;115(5):1311-1321. doi: 10.1093/ajcn/nqac022.
  4. Congy-Jolivet N, Cenac C, Dellacasagrande J, Puissant-Lubrano B, Apoil PA, Guedj K, Abbas F, Laffont S, Sourdet S, Guyonnet S, Nourhashemi F, Guéry JC, Blancher A. Monocytes are the main source of STING-mediated IFN-α production. EBioMedicine. 2022 Jun;80:104047. doi: 10.1016/j.ebiom.2022.104047.
  5. de Godoi Rezende Costa Molino C, Chocano-Bedoya PO, Sadlon A, Theiler R, Orav JE, Vellas B, Rizzoli R, Kressig RW, Kanis JA, Guyonnet S, Lang W, Egli A, Bischoff-Ferrari HA; DO-HEALTH Research Group. Prevalence of polypharmacy in community-dwelling older adults from seven centres in five European countries: a cross-sectional study of DO-HEALTH. BMJ Open. 2022 Apr 29;12(4):e051881. doi: 10.1136/bmjopen-2021-051881.
  6. Fougère B, Goisser S, Cantet C, Soriano G, Guyonnet S, De Souto Barreto P, Cesari M, Andrieu S, Vellas B; MAPT Study Group. Retraction Note to: Omega-3 fatty acid levels in red blood cell membranes and physical decline over 3 years: longitudinal data from the MAPT study. Geroscience. 2022 Apr;44(2):1173. doi: 10.1007/s11357-021-00505-z.
  7. Gagesch M, Chocano-Bedoya PO, Abderhalden LA, Freystaetter G, Sadlon A, Kanis JA, Kressig RW, Guyonnet S, DaSilva JAP, Felsenberg D, Rizzoli R, Blauth M, Orav EJ, Egli A, Bischoff-Ferrari HA. Prevalence of Physical Frailty: Results from the DO-HEALTH Study. J Frailty Aging. 2022;11(1):18-25. doi: 10.14283/jfa.2021.18.
  8. Gängler S, Steiner H, Gagesch M, Guyonnet S, Orav EJ, von Eckardstein A, Willett WC, Bischoff-Ferrari HA. Adherence to the Mediterranean Diet and Incidence of Pre-Frailty and Frailty in Community-Dwelling Adults 70+: The 3-Year DO-HEALTH Study. Nutrients. 2022 Oct 6;14(19):4145. doi: 10.3390/nu14194145.
  9. Giudici KV, Barreto PS, Guyonnet S, Morley JE, Nguyen AD, Aggarwal G, Parini A, Li Y, Bateman RJ, Vellas B; MAPT/DSA group. TNFR-1 and GDF-15 are associated with plasma neurofilament light chain and progranulin among community-dwelling older adults: a secondary analysis of the MAPT Study. J Gerontol A Biol Sci Med Sci. 2022 Dec 12:glac244. doi: 10.1093/gerona/glac244. Epub ahead of print.
  10. Giudici KV, Guyonnet S, Cantet C, de Souto Barreto P, Weiner MW, Tosun D, Boschat C, Hudry J, Andrieu S, Vellas B, Schmitt JAJ; Nolan/DSA group. A 1-year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community-dwelling older adults: The Nolan Study. Alzheimers Dement (N Y). 2022 Sep 28;8(1):e12314. doi: 10.1002/trc2.12314.
  11. Giudici KV, Guyonnet S, Morley JE, Nguyen AD, Aggarwal G, Parini A, Li Y, Bateman RJ, Vellas B, Barreto PS; MAPT/DSA group. Interactions between weight loss and plasma neurodegenerative markers for determining cognitive decline among community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2022 Jun 1;77(6):1159-1168. . doi: 10.1093/gerona/glac015.
  12. He L, de Souto Barreto P, Sánchez Sánchez JL, Rolland Y, Guyonnet S, Parini A, Lucas A, Vellas B; MAPT/DSA Group. Prospective Associations of Plasma Growth Differentiation Factor 15 With Physical Performance and Cognitive Functions in Older Adults. J Gerontol A Biol Sci Med Sci. 2022 Dec 29;77(12):2420-2428. doi: 10.1093/gerona/glac020.
  13. Lu WH, Giudici KV, Guyonnet S, Aggarwal G, Nguyen AD, Morley JE, Vellas B, de Souto Barreto P; MAPT/DSA Group. Associations of plasma neurofilament light chain and progranulin with frailty in older adults. J Am Geriatr Soc. 2022 Apr;70(4):1236-1243. doi: 10.1111/jgs.17604.
  14. Lu WH, Giudici KV, Morley JE, Guyonnet S, Parini A, Aggarwal G, Nguyen AD, Li Y, Bateman RJ, Vellas B, de Souto Barreto P; MAPT/DSA Group. Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults. Geroscience. 2022 Jun;44(3):1489-1503 . doi: 10.1007/s11357-022-00554-y.
  15. Molet-Benhamou L, Giudici KV, de Souto Barreto P, Cantet C, Rolland Y; MAPT/DSA group (Guyonnet S collaborator). Association between urate-lowering therapies and cognitive decline in community-dwelling older adults. Sci Rep. 2022 Sep 12;12(1):15299. doi: 10.1038/s41598-022-17808-6.
  16. Pagès A, Costa N, Mounié M, Cestac P, De Souto Barreto P, Rolland Y, Vellas B, Molinier L, Juillard-Condat B; MAPT/DSA Group (Vellas B, Guyonnet S collaborators). Healthcare Costs Associated with Potentially Inappropriate Medication Prescribing Detected by Computer Algorithm Among Older Patients. Drugs Aging. 2022 May;39(5):367-375. doi: 10.1007/s40266-022-00938-x.
  17. Raffin J, Angioni D, Giudici KV, Valet P, Aggarwal G, Nguyen AD, Morley JE, Guyonnet S, Rolland Y, Vellas B, Barreto PS; MAPT/DSA Group. Physical activity, body mass index, and blood progranulin in older adults: cross-sectional associations in the MAPT study. J Gerontol A Biol Sci Med Sci. 2022 Jun 1;77(6):1141-1149. doi: 10.1093/gerona/glac018.
  18. Rouch L, Virecoulon Giudici K, Cantet C, Guyonnet S, Delrieu J, Legrand P, Catheline D, Andrieu S, Weiner M, de Souto Barreto P, Vellas B; Alzheimer's Disease Neuroimaging Initiative. Associations of erythrocyte omega-3 fatty acids with cognition, brain imaging and biomarkers in the Alzheimer's disease neuroimaging initiative: cross-sectional and longitudinal retrospective analyses. Am J Clin Nutr. 2022 Dec 19;116(6):1492-1506. doi: 10.1093/ajcn/nqac236
  19. Sanchez-Sanchez JL, Giudici KV, Guyonnet S, Delrieu J, Li Y, Bateman RJ, Parini A, Vellas B, de Souto Barreto P; MAPT/DSA Group. Plasma MCP-1 and changes on cognitive function in community-dwelling older adults. Alzheimers Res Ther. 2022 Jan 7;14(1):5. doi: 10.1186/s13195-021-00940-2.
  20. Sanchez-Sanchez JL, He L, Virecoulon Giudici K, Guyonnet S, Parini A, Dray C, Valet P, Pereira O, Vellas B, Rolland Y, de Souto Barreto P. Circulating Levels of Apelin, GDF-15 and Sarcopenia: Lack of Association in the MAPT Study. J Nutr Health Aging. 2022;26(6):564-570. doi: 10.1007/s12603-022-1800-1.
  21. Stahl-Gugger A, de Godoi Rezende Costa Molino C, Wieczorek M, Chocano-Bedoya PO, Abderhalden LA, Schaer DJ, Spahn DR, Orav EJ, Vellas B, da Silva JAP, Kressig RW, Egli A, Bischoff-Ferrari HA; DO-HEALTH Research Group (Guyonnet S collaborator). Prevalence and incidence of iron deficiency in European community-dwelling older adults: an observational analysis of the DO-HEALTH trial. Aging Clin Exp Res. 2022 Sep;34(9):2205-2215. doi: 10.1007/s40520-022-02093-0.
Sophie GUYONNET •   PUBLICATIONS 2021  PUBLICATIONS 2020  • PUBLICATIONS 2019