MAINTAIN - MAintain Functions and INTrinsec capacities with Aging :
Preventive and personalized INterventional Research

Equipe constitutive du CERPOP, UMR1295, unité mixte INSERM - Université Toulouse III Paul Sabatier
Sophie GUYONNET •  chercheure



2023

  1. Aggarwal G, Morley JE, Vellas B, Nguyen AD, Butler AA; MAPT/DSA Group (Guyonnet S collaborator). Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults. Geroscience. 2023 May 26. doi: 10.1007/s11357-023-00824-3. Epub ahead of print.
  2. Bencivenga L, Strumia M, Rolland Y, Martinez L, Cestac P, Guyonnet S, Andrieu S, Parini A, Lucas A, Vellas B, De Souto Barreto P, Rouch L; MAPT/D. S. A. group. Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability. Geroscience. 2023 Apr;45(2):797-809. doi: 10.1007/s11357-022-00697-y.
  3. Boureau AS, Guyomarch B, Gourdy P, Allix I, Annweiler C, Cervantes N, Chapelet G, Delabrière I, Guyonnet S, Litke R, Paccalin M, Penfornis A, Saulnier PJ, Wargny M, Hadjadj S, de Decker L, Cariou B. Nocturnal hypoglycemia is underdiagnosed in older people with insulin-treated type 2 diabetes: The HYPOAGE observational study. J Am Geriatr Soc. 2023 Jul;71(7):2107-2119. doi: 10.1111/jgs.18341.
  4. Grande de França NA, Rolland Y, Guyonnet S, de Souto Barreto P. The role of dietary strategies in the modulation of hallmarks of aging. Ageing Res Rev. 2023 Jun;87:101908. doi: 10.1016/j.arr.2023.101908.
  5. Giudici KV, de Souto Barreto P, Guyonnet S, Morley JE, Nguyen AD, Aggarwal G, Parini A, Li Y, Bateman RJ, Vellas B; MAPT/DSA Group. TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study. J Gerontol A Biol Sci Med Sci. 2023 Mar 30;78(4):569-578. doi: 10.1093/gerona/glac244.
  6. Lu WH, Gonzalez-Bautista E, Guyonnet S, Lucas A, Parini A, Walston JD, Vellas B, de Souto Barreto P; MAPT/DSA Group. Plasma inflammation-related biomarkers are associated with intrinsic capacity in community-dwelling older adults. J Cachexia Sarcopenia Muscle. 2023 Apr;14(2):930-939. doi: 10.1002/jcsm.13163.
  7. Pires Da Silva J, Wargny M, Raffin J, Croyal M, Duparc T, Combes G, Genoux A, Perret B, Vellas B, Guyonnet S, Thalamas C, Langin D, Moro C, Viguerie N, Rolland Y, Barreto PS, Cariou B, Martinez LO; MAPT/DSA Group. Plasma level of ATPase inhibitory factor 1 (IF1) is associated with type 2 diabetes risk in humans: A prospective cohort study. Diabetes Metab. 2023 Jan;49(1):101391. doi: 10.1016/j.diabet.2022.101391.
  8. Raffin J, Rolland Y, Parini A, Lucas A, Guyonnet S, Vellas B, de Souto Barreto P; MAPT/DSA Group. Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis. J Cachexia Sarcopenia Muscle. 2023 Jan 20;14(2):771–80. doi: 10.1002/jcsm.13152. Epub ahead of print.
  9. Silva JAD, Martinez LO, Rolland Y, Najib S, Croyal M, Perret B, Jabrane-Ferrat N, El Costa H, Guyonnet S, Vellas B, Barreto PS; MAPT/DSA group. Plasma Level of ATPase Inhibitory Factor 1 (IF1) and intrinsic capacity in community-dwelling older adults: Prospective data from the MAPT Study. J Gerontol A Biol Sci Med Sci. 2023 Jun 6:glad142. doi: 10.1093/gerona/glad142. Epub ahead of print.
2022
  1. Angioni D, Lu WH, Sourdet S, Macaron T, Takeda C, Guyonnet S, Mangin JF, Rolland Y, de Souto Barreto P, Vellas B. Biomarkers of Age-Related Frailty and Frailty Related to Diseases: An Exploratory, Cross-Sectional Analysis from the MAPT Study. J Nutr Health Aging. 2022;26(6):545-551. doi: 10.1007/s12603-022-1793-9.
  2. Bernabei R, Landi F, Calvani R, Cesari M, Del Signore S, Anker SD, Bejuit R, Bordes P, Cherubini A, Cruz-Jentoft AJ, Di Bari M, Friede T, Gorostiaga Ayestarán C, Goyeau H, Jónsson PV, Kashiwa M, Lattanzio F, Maggio M, Mariotti L, Miller RR, Rodriguez-Mañas L, Roller-Wirnsberger R, Rýznarová I, Scholpp J, Schols AMWJ, Sieber CC, Sinclair AJ, Skalska A, Strandberg T, Tchalla A, Topinková E, Tosato M, Vellas B, von Haehling S, Pahor M, Roubenoff R, Marzetti E; SPRINTT consortium (Guyonnet S collaborator). Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project). BMJ. 2022 May 11;377:e068788. doi: 10.1136/bmj-2021-068788.
  3. Bischoff-Ferrari HA, Freystätter G, Vellas B, Dawson-Hughes B, Kressig RW, Kanis JA, Willett WC, Manson JE, Rizzoli R, Theiler R, Hofbauer LC, Armbrecht G, da Silva JAP, Blauth M, de Godoi Rezende Costa Molino C, Lang W, Siebert U, Egli A, Orav EJ, Wieczorek M; DO-HEALTH Research Group (Guyonnet S collaborator). Effects of vitamin D, omega-3 fatty acids and a simple home strength exercise program on fall prevention: the DO-HEALTH randomized clinical trial. Am J Clin Nutr. 2022 May 1;115(5):1311-1321. doi: 10.1093/ajcn/nqac022.
  4. Congy-Jolivet N, Cenac C, Dellacasagrande J, Puissant-Lubrano B, Apoil PA, Guedj K, Abbas F, Laffont S, Sourdet S, Guyonnet S, Nourhashemi F, Guéry JC, Blancher A. Monocytes are the main source of STING-mediated IFN-α production. EBioMedicine. 2022 Jun;80:104047. doi: 10.1016/j.ebiom.2022.104047.
  5. de Godoi Rezende Costa Molino C, Chocano-Bedoya PO, Sadlon A, Theiler R, Orav JE, Vellas B, Rizzoli R, Kressig RW, Kanis JA, Guyonnet S, Lang W, Egli A, Bischoff-Ferrari HA; DO-HEALTH Research Group. Prevalence of polypharmacy in community-dwelling older adults from seven centres in five European countries: a cross-sectional study of DO-HEALTH. BMJ Open. 2022 Apr 29;12(4):e051881. doi: 10.1136/bmjopen-2021-051881.
  6. Fougère B, Goisser S, Cantet C, Soriano G, Guyonnet S, De Souto Barreto P, Cesari M, Andrieu S, Vellas B; MAPT Study Group. Retraction Note to: Omega-3 fatty acid levels in red blood cell membranes and physical decline over 3 years: longitudinal data from the MAPT study. Geroscience. 2022 Apr;44(2):1173. doi: 10.1007/s11357-021-00505-z.
  7. Gagesch M, Chocano-Bedoya PO, Abderhalden LA, Freystaetter G, Sadlon A, Kanis JA, Kressig RW, Guyonnet S, DaSilva JAP, Felsenberg D, Rizzoli R, Blauth M, Orav EJ, Egli A, Bischoff-Ferrari HA. Prevalence of Physical Frailty: Results from the DO-HEALTH Study. J Frailty Aging. 2022;11(1):18-25. doi: 10.14283/jfa.2021.18.
  8. Gängler S, Steiner H, Gagesch M, Guyonnet S, Orav EJ, von Eckardstein A, Willett WC, Bischoff-Ferrari HA. Adherence to the Mediterranean Diet and Incidence of Pre-Frailty and Frailty in Community-Dwelling Adults 70+: The 3-Year DO-HEALTH Study. Nutrients. 2022 Oct 6;14(19):4145. doi: 10.3390/nu14194145.
  9. Giudici KV, Barreto PS, Guyonnet S, Morley JE, Nguyen AD, Aggarwal G, Parini A, Li Y, Bateman RJ, Vellas B; MAPT/DSA group. TNFR-1 and GDF-15 are associated with plasma neurofilament light chain and progranulin among community-dwelling older adults: a secondary analysis of the MAPT Study. J Gerontol A Biol Sci Med Sci. 2022 Dec 12:glac244. doi: 10.1093/gerona/glac244. Epub ahead of print.
  10. Giudici KV, Guyonnet S, Cantet C, de Souto Barreto P, Weiner MW, Tosun D, Boschat C, Hudry J, Andrieu S, Vellas B, Schmitt JAJ; Nolan/DSA group. A 1-year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community-dwelling older adults: The Nolan Study. Alzheimers Dement (N Y). 2022 Sep 28;8(1):e12314. doi: 10.1002/trc2.12314.
  11. Giudici KV, Guyonnet S, Morley JE, Nguyen AD, Aggarwal G, Parini A, Li Y, Bateman RJ, Vellas B, Barreto PS; MAPT/DSA group. Interactions between weight loss and plasma neurodegenerative markers for determining cognitive decline among community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2022 Jun 1;77(6):1159-1168. . doi: 10.1093/gerona/glac015.
  12. He L, de Souto Barreto P, Sánchez Sánchez JL, Rolland Y, Guyonnet S, Parini A, Lucas A, Vellas B; MAPT/DSA Group. Prospective Associations of Plasma Growth Differentiation Factor 15 With Physical Performance and Cognitive Functions in Older Adults. J Gerontol A Biol Sci Med Sci. 2022 Dec 29;77(12):2420-2428. doi: 10.1093/gerona/glac020.
  13. Lu WH, Giudici KV, Guyonnet S, Aggarwal G, Nguyen AD, Morley JE, Vellas B, de Souto Barreto P; MAPT/DSA Group. Associations of plasma neurofilament light chain and progranulin with frailty in older adults. J Am Geriatr Soc. 2022 Apr;70(4):1236-1243. doi: 10.1111/jgs.17604.
  14. Lu WH, Giudici KV, Morley JE, Guyonnet S, Parini A, Aggarwal G, Nguyen AD, Li Y, Bateman RJ, Vellas B, de Souto Barreto P; MAPT/DSA Group. Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults. Geroscience. 2022 Jun;44(3):1489-1503 . doi: 10.1007/s11357-022-00554-y.
  15. Molet-Benhamou L, Giudici KV, de Souto Barreto P, Cantet C, Rolland Y; MAPT/DSA group (Guyonnet S collaborator). Association between urate-lowering therapies and cognitive decline in community-dwelling older adults. Sci Rep. 2022 Sep 12;12(1):15299. doi: 10.1038/s41598-022-17808-6.
  16. Pagès A, Costa N, Mounié M, Cestac P, De Souto Barreto P, Rolland Y, Vellas B, Molinier L, Juillard-Condat B; MAPT/DSA Group (Vellas B, Guyonnet S collaborators). Healthcare Costs Associated with Potentially Inappropriate Medication Prescribing Detected by Computer Algorithm Among Older Patients. Drugs Aging. 2022 May;39(5):367-375. doi: 10.1007/s40266-022-00938-x.
  17. Raffin J, Angioni D, Giudici KV, Valet P, Aggarwal G, Nguyen AD, Morley JE, Guyonnet S, Rolland Y, Vellas B, Barreto PS; MAPT/DSA Group. Physical activity, body mass index, and blood progranulin in older adults: cross-sectional associations in the MAPT study. J Gerontol A Biol Sci Med Sci. 2022 Jun 1;77(6):1141-1149. doi: 10.1093/gerona/glac018.
  18. Rouch L, Virecoulon Giudici K, Cantet C, Guyonnet S, Delrieu J, Legrand P, Catheline D, Andrieu S, Weiner M, de Souto Barreto P, Vellas B; Alzheimer's Disease Neuroimaging Initiative. Associations of erythrocyte omega-3 fatty acids with cognition, brain imaging and biomarkers in the Alzheimer's disease neuroimaging initiative: cross-sectional and longitudinal retrospective analyses. Am J Clin Nutr. 2022 Dec 19;116(6):1492-1506. doi: 10.1093/ajcn/nqac236
  19. Sanchez-Sanchez JL, Giudici KV, Guyonnet S, Delrieu J, Li Y, Bateman RJ, Parini A, Vellas B, de Souto Barreto P; MAPT/DSA Group. Plasma MCP-1 and changes on cognitive function in community-dwelling older adults. Alzheimers Res Ther. 2022 Jan 7;14(1):5. doi: 10.1186/s13195-021-00940-2.
  20. Sanchez-Sanchez JL, He L, Virecoulon Giudici K, Guyonnet S, Parini A, Dray C, Valet P, Pereira O, Vellas B, Rolland Y, de Souto Barreto P. Circulating Levels of Apelin, GDF-15 and Sarcopenia: Lack of Association in the MAPT Study. J Nutr Health Aging. 2022;26(6):564-570. doi: 10.1007/s12603-022-1800-1.
  21. Stahl-Gugger A, de Godoi Rezende Costa Molino C, Wieczorek M, Chocano-Bedoya PO, Abderhalden LA, Schaer DJ, Spahn DR, Orav EJ, Vellas B, da Silva JAP, Kressig RW, Egli A, Bischoff-Ferrari HA; DO-HEALTH Research Group (Guyonnet S collaborator). Prevalence and incidence of iron deficiency in European community-dwelling older adults: an observational analysis of the DO-HEALTH trial. Aging Clin Exp Res. 2022 Sep;34(9):2205-2215. doi: 10.1007/s40520-022-02093-0.
2021
  1. Ader I, Pénicaud L, Andrieu S, Beard JR, Davezac N, Dray C, Fazilleau N, Gourdy P, Guyonnet S, Liblau R, Parini A, Payoux P, Rampon C, Raymond-Letron I, Rolland Y, de Souto Barreto P, Valet P, Vergnolle N, Sierra F, Vellas B, Casteilla L. Healthy Aging Biomarkers: The INSPIRE's Contribution. J Frailty Aging. 2021;10(4):313-319. doi: 10.14283/jfa.2021.15.
  2. Costa N, Mounié M, Pagès A, Derumeaux H, Rapp T, Guyonnet S, Coley N, Cantet C, Carrié I, Andrieu S, Molinier L. The Cost-Effectiveness of Three Prevention Strategies in Alzheimer's Disease: Results from the Multidomain Alzheimer Preventive Trial (MAPT). J Prev Alzheimers Dis. 2021;8(4):425-435. doi: 10.14283/jpad.2021.47.
  3. de Souto Barreto P, Guyonnet S, Ader I, Andrieu S, Casteilla L, Davezac N, Dray C, Fazilleau N, Gourdy P, Liblau R, Parini A, Payoux P, Pénicaud L, Rampon C, Rolland Y, Valet P, Vergnolle N, Vellas B. The INSPIRE Research Initiative: A Program for GeroScience and Healthy Aging Research Going from Animal Models to Humans and the Healthcare System. J Frailty Aging. 2021;10(2):86-93. doi: 10.14283/jfa.2020.18.
  4. de Souto Barreto P, Pothier K, Soriano G, Lussier M, Bherer L, Guyonnet S, Piau A, Ousset PJ, Vellas B. A Web-Based Multidomain Lifestyle Intervention for Older Adults: The eMIND Randomized Controlled Trial. J Prev Alzheimers Dis. 2021;8(2):142-150. doi: 10.14283/jpad.2020.70.
  5. Guyonnet S, Rolland Y, Takeda C, Ousset PJ, Ader I, Davezac N, Dray C, Fazilleau N, Gourdy P, Liblau R, Parini A, Payoux P, Pénicaud L, Rampon C, Valet P, Vergnolle N, Andrieu S, de Souto Barreto P, Casteilla L, Vellas B. The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort). J Frailty Aging. 2021;10(2):110-120. doi: 10.14283/jfa.2020.38.
  6. He L, de Souto Barreto P, Giudici KV, Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, Vellas B; MAPT/DSA Group (Guyonnet S collaborator). Cross-Sectional and Longitudinal Associations Between Plasma Neurodegenerative Biomarkers and Physical Performance Among Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1874-1881. doi: 10.1093/gerona/glaa284.
  7. He L, Morley JE, Aggarwal G, Nguyen AD, Vellas B, de Souto Barreto P; MAPT/DSA Group (Guyonnet S collaborator). Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults. Sci Rep. 2021 Jun 28;11(1):13394. doi: 10.1038/s41598-021-91038-0.
  8. Jyväkorpi SK, Ramel A, Strandberg TE, Piotrowicz K, Błaszczyk-Bębenek E, Urtamo A, Rempe HM, Geirsdóttir Ó, Vágnerová T, Billot M, Larreur A, Savera G, Soriano G, Picauron C, Tagliaferri S, Sanchez-Puelles C, Cadenas VS, Perl A, Tirrel L, Öhman H, Weling-Scheepers C, Ambrosi S, Costantini A, Pavelková K, Klimkova M, Freiberger E, Jonsson PV, Marzetti E, Pitkälä KH, Landi F, Calvani R; SPRINTT consortium (Guyonnet S collaborator). The sarcopenia and physical frailty in older people: multi-component treatment strategies (SPRINTT) project: description and feasibility of a nutrition intervention in community-dwelling older Europeans. Eur Geriatr Med. 2021 Apr;12(2):303-312. doi: 10.1007/s41999-020-00438-4.
  9. Lafaurie M, Martin-Blondel G, Delobel P, Kamar N, Charpentier S, Sommet A, Moulis G; Covid-Clinic-Toul investigators (Guyonnet S collaborator). Impact of previous exposure to systemic corticosteroids on unfavorable outcome in patients hospitalized for COVID-19. BMC Pharmacol Toxicol. 2021 Mar 11;22(1):14. doi: 10.1186/s40360-021-00480-3.
  10. Lu WH, de Souto Barreto P, Rolland Y, Bouyahia A, Fischer C, Mangin JF, Giudici KV, Vellas B; MAPT/DSA Group (Guyonnet S collaborator).. Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study. J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):e361-e369. doi: 10.1093/gerona/glaa296.
  11. Lu WH, Giudici KV, Rolland Y, Guyonnet S, Mangin JF, Vellas B, de Souto Barreto P. Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults. Front Nutr. 2021 Nov 11;8:771470. doi: 10.3389/fnut.2021.771470.
  12. Lu WH, Giudici KV, Rolland Y, Guyonnet S, Li Y, Bateman RJ, de Souto Barreto P, Vellas B. Prospective Associations between Plasma Amyloid-Beta 42/40 and Frailty in Community-Dwelling Older Adults. J Prev Alzheimers Dis. 2021;8(1):41-47. doi: 10.14283/jpad.2020.60.
  13. Raffin J, Rolland Y, Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, Vellas B, Barreto PS; MAPT/DSA Group (Guyonnet S collaborator). Associations Between Physical Activity, Blood-Based Biomarkers of Neurodegeneration, and Cognition in Healthy Older Adults: The MAPT Study. J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):1382-1390. doi: 10.1093/gerona/glab094.
  14. Rouch L, De Souto Barreto P, Hanon O, Vidal JS, Amar J, Andrieu S, Cestac P, Rolland Y, Vellas B; MAPT/DSA Group (Guyonnet S collaborator). Visit-to-Visit Blood Pressure Variability and Incident Frailty in Older Adults. J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):1369-1375. doi: 10.1093/gerona/glab112.
  15. Santin Y, Lopez S, Ader I, Andrieu S, Blanchard N, Carrière A, Casteilla L, Cousin B, Davezac N, De Souto Barreto P, Dray C, Fazilleau N, Gonzalez-Dunia D, Gourdy P, Guyonnet S, Jabrane-Ferrat N, Kunduzova O, Lezoualc'h F, Liblau R, Martinez LO, Moro C, Payoux P, Pénicaud L, Planat-Bénard V, Rampon C, Rolland Y, Schanstra JP, Sierra F, Valet P, Varin A, Vergnolle N, Vellas B, Viña J, Guiard BP, Parini A. Towards a Large-Scale Assessment of the Relationship between Biological and Chronological Aging: The INSPIRE Mouse Cohort. J Frailty Aging. 2021;10(2):121-131. doi: 10.14283/jfa.2020.43.
  16. Sourdet S, Soriano G, Delrieu J, Steinmeyer Z, Guyonnet S, Saint-Aubert L, Payoux P, Ousset PJ, Ghisolfi A, Chicoulaa B, Dardenne S, Gemar T, Baziard M, Guerville F, Andrieu S, Vellas B. Cognitive Function and Amyloid Marker in Frail Older Adults: The COGFRAIL Cohort Study. J Frailty Aging. 2021;10(2):160-167. doi: 10.14283/jfa.2020.57.
  17. Takano E, Maltais M, Kondo I, Rolland Y; MAPT/DSA group (Guyonnet S collaborator). Bidirectional relationship between depressive symptoms and physical performance in community-dwelling older people with subjective memory complaints. Eur Geriatr Med. 2021 Oct;12(5):973-980. doi: 10.1007/s41999-021-00473-9.
  18. Tavassoli N, Piau A, Berbon C, De Kerimel J, Lafont C, De Souto Barreto P, Guyonnet S, Takeda C, Carrie I, Angioni D, Paris F, Mathieu C, Ousset PJ, Balardy L, Voisin T, Sourdet S, Delrieu J, Bezombes V, Pons-Pretre V, Andrieu S, Nourhashemi F, Rolland Y, Soto ME, Beard J, Sumi Y, Araujo Carvalho I, Vellas B. Framework Implementation of the INSPIRE ICOPE-CARE Program in Collaboration with the World Health Organization (WHO) in the Occitania Region. J Frailty Aging. 2021;10(2):103-109. doi: 10.14283/jfa.2020.26.
Sophie GUYONNET •  PUBLICATIONS 2020  • PUBLICATIONS 2019