SPHERE - Study of Perinatal, paediatric and adolescent Health : Epidemiological Research and Evaluation
Equipe constitutive du CERPOP, UMR1295, unité mixte de recherche Inserm – Université Toulouse III Paul Sabatier
Sophie BREINIG •  doctorante


  1. Alberge C, Ehlinger V, Noack N, Bolzoni C, Colombié B, Breinig S, Dicky O, Delobel M, Arnaud C. Early psychomotor therapy in very preterm infants does not improve Bayley-III scales at 2 years. Acta Paediatr. 2023 Sep;112(9):1916-1925. doi: 10.1111/apa.16848.
  2. Breinig S, Ehlinger V, Rozé JC, Storme L, Torchin H, Durrmeyer X, Cambonie G, Delacourt C, Jarreau PH, Berthomieu L, Brissaud O, Benhammou V, Gascoin G, Arnaud C, Ancel PY. Pulmonary hypertension among preterm infants born at 22 through 32 weeks gestation in France: Prevalence, survival, morbidity and management in the EPIPAGE-2 cohort study. Early Hum Dev. 2023 Sep;184:105837. doi: 10.1016/j.earlhumdev.2023.105837.
2023 Publications cliniques
  1. Milési C, Baudin F, Durand P, Emeriaud G, Essouri S, Pouyau R, Baleine J, Beldjilali S, Bordessoule A, Breinig S, Demaret P, Desprez P, Gaillard-Leroux B, Guichoux J, Guilbert AS, Guillot C, Jean S, Levy M, Noizet-Yverneau O, Rambaud J, Recher M, Reynaud S, Valla F, Radoui K, Faure MA, Ferraro G, Mortamet G; French Speaking Group for Pediatric Intensive and Emergency Care. Clinical practice guidelines: management of severe bronchiolitis in infants under 12 months old admitted to a pediatric critical care unit. Intensive Care Med. 2023 Jan;49(1):5-25. doi: 10.1007/s00134-022-06918-4.


  1. Collignon AM, Vergnes JN, Germa A, Azogui S, Breinig S, Hollande C, Bonnet AL, Nabet C. Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review. Front Pediatr. 2022 Feb 24;10:836708. doi: 10.3389/fped.2022.836708.


  1. Breinig S, Dicky O, Ehlinger V, Dulac Y, Marcoux MO, Arnaud C. Echocardiographic Parameters Predictive of Poor Outcome in Persistent Pulmonary Hypertension of the Newborn (PPHN): Preliminary Results. Pediatr Cardiol. 2021 Dec;42(8):1848-1853. doi: 10.1007/s00246-021-02677-z.
  2. Breinig S, Mortamet G, Brossier D, Amadieu R, Claudet I, Javouhey E, Angoulvant F, Arnaud C. Impact of the French National Lockdown on Admissions to 14 Pediatric Intensive Care Units During the 2020 COVID-19 Pandemic-A Retrospective Multicenter Study. Front Pediatr. 2021 Dec 10;9:764583. doi: 10.3389/fped.2021.764583.
  3. Chahine A, Chenouard A, Joram N, Berthomieu L, Du Pont-Thibodeau G, Leclere B, Liet JM, Maminirina P, Leclair-Visonneau L, Breinig S, Bourgoin P. Continuous Amplitude-Integrated Electroencephalography During Neonatal and Pediatric Extracorporeal Membrane Oxygenation. J Clin Neurophysiol. 2021 Aug 9. doi: 10.1097/WNP.0000000000000890. Epub ahead of print.
  4. Leobon B, Cousin G, Hadeed K, Breinig S, Alacoque X, Berthomieu L, Karsenty C. Tetralogy of Fallot: T-shaped infundibulotomy for pulmonary valve-sparing procedure. Interact Cardiovasc Thorac Surg. 2021 Oct 4:ivab275. doi: 10.1093/icvts/ivab275.
  5. Pierrat V, Marchand-Martin L, Marret S, Arnaud C, Benhammou V, Cambonie G, Debillon T, Dufourg MN, Gire C, Goffinet F, Kaminski M, Lapillonne A, Morgan AS, Rozé JC, Twilhaar S, Charles MA, Ancel PY; EPIPAGE-2 writing group (Breinig S,.collaborator) Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study. BMJ. 2021 Apr 28;373:n741. doi: 10.1136/bmj.n741.
  6. Tauzin M, Marchand-Martin L, Lebeaux C, Breinig S, Claris O, Tourneux P, Alexandre C, Levy C, Jung C, Dechartres A, Durrmeyer X; PREmedication Trial for Tracheal Intubation of the NEOnate Research Group. Neurodevelopmental Outcomes after Premedication with Atropine/Propofol vs Atropine/Atracurium/Sufentanil for Neonatal Intubation: 2-Year Follow-Up of a Randomized Clinical Trial. J Pediatr. 2021 Apr;231:273-277.e3. doi: 10.1016/j.jpeds.2020.12.001.


  1. Brehin C, Dubois D, Dicky O, Breinig S, Oswald E, Serino M. Evolution of Gut Microbiome and Metabolome in Suspected Necrotizing Enterocolitis: A Case-Control Study. J Clin Med. 2020 Jul 17;9(7):2278. doi: 10.3390/jcm9072278.
  2. Claudet I, Breinig S, Lavit M, Ricco L, Brehin C, El Balkhi S. Is there an interest for hair analysis in non-intentional pediatric cannabis intoxication? Forensic Sci Int. 2020 Aug;313:110377. doi: 10.1016/j.forsciint.2020.110377.
  1. Vedrenne-Cloquet M, Breinig S, Dechartres A, Jung C, Renolleau S, Marchand-Martin L, Durrmeyer X. Cerebral Oxygenation During Neonatal Intubation-Ancillary Study of the Prettineo-Study. Front Pediatr. 2019 Mar 1;7:40. doi: 10.3389/fped.2019.00040.