MAINTAIN - MAintain Functions and INTrinsec capacities with Aging :
Preventive and personalized INterventional Research

Equipe constitutive du CERPOP, UMR 1295, unité mixte INSERM - Université Toulouse III Paul Sabatier
Philippe CESTAC •  chercheur


  1. Novais T, Qassemi S, Cestac P, McCambridge C, Villars H, Zueras A, Decaudin B, Dambrine M, Huvent-Grelle D, Roche J, Schoenenburg S, Federico D, Nier AC, Krolak-Salmon P, Mouchoux C. Impact of pharmaceutical care integrated at a psychosocial intervention to reduce caregiver's burden in Alzheimer's disease or related dementias: Negative results at 18 months and difficulties to conduct PHARMAID RCT. Contemp Clin Trials Commun. 2023 Apr 22;33:101146. doi: 10.1016/j.conctc.2023.101146.
  2. Bencivenga L, Strumia M, Rolland Y, Martinez L, Cestac P, Guyonnet S, Andrieu S, Parini A, Lucas A, Vellas B, De Souto Barreto P, Rouch L; MAPT/D. S. A. group. Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability. Geroscience. 2023 Apr;45(2):797-809. doi: 10.1007/s11357-022-00697-y.
  3. Malham CB, Khatib SE, Strumia M, Andrieu S, Cestac P, Salameh P. The MGPIDP-L project: Potentially inappropriate drug prescribing and its associated factors. Arch Gerontol Geriatr. 2023 Jun;109:104947. doi: 10.1016/j.archger.2023.104947.
  4. Taillefer de Laportalière T, Jullien A, Yrondi A, Cestac P, Montastruc F. Reporting of harms in clinical trials of esketamine in depression: a systematic review. Psychol Med. 2023 Apr 26:1-11. doi: 10.1017/S0033291723001058. Epub ahead of print.


  1. Bencivenga L, De Souto Barreto P, Rolland Y, Hanon O, Vidal JS, Cestac P, Vellas B, Rouch L. Blood pressure variability: A potential marker of aging. Ageing Res Rev. 2022 Sep;80:101677. doi: 10.1016/j.arr.2022.101677.
  2. Guillotin S, Vallet A, Lorthois S, Cestac P, Schmidt E, Delcourt N. Association between Homocysteine, Frailty and Biomechanical Response of the CNS in NPH-suspected Patients. J Gerontol A Biol Sci Med Sci. 2022 Jul 5;77(7):1335-1343. doi: 10.1093/gerona/glac074. Epub ahead of print.
  3. Lohan L, Cool C, Viault L, Cestac P, Renard E, Galtier F, Villiet M, Avignon A, Sultan A, Breuker C. Impact of Hospitalization in an Endocrinology Department on Vaccination Coverage in People Living with Diabetes: A Real-Life Study. Medicina (Kaunas). 2022 Feb 1;58(2):219. doi: 10.3390/medicina58020219.
  4. Pagès A, Costa N, Mounié M, Cestac P, De Souto Barreto P, Rolland Y, Vellas B, Molinier L, Juillard-Condat B; MAPT/DSA Group. Healthcare Costs Associated with Potentially Inappropriate Medication Prescribing Detected by Computer Algorithm Among Older Patients. Drugs Aging. 2022 May;39(5):367-375. doi: 10.1007/s40266-022-00938-x.
  5. Pagès A, Costa N, González-Bautista E, Mounié M, Juillard-Condat B, Molinier L, Cestac P, Rolland Y, Vellas B, De Souto Barreto P; MAPT/DSA Group. Screening for deficits on intrinsic capacity domains and associated healthcare costs. Arch Gerontol Geriatr. 2022 May-Jun;100:104654. doi: 10.1016/j.archger.2022.104654.
  6. Rouch L, Rolland Y, Hanon O, Vidal JS, Cestac P, Sallerin B, Andrieu S, Vellas B, Barreto PS; MAPT/DSA Group. Blood pressure, antihypertensive drugs, and incident frailty: The Multidomain Alzheimer Preventive Trial (MAPT). Maturitas. 2022 Aug;162:8-14.. doi: 10.1016/j.maturitas.2022.03.001.


  1. Bou Malham C, El Khatib S, Cestac P, Andrieu S, Rouch L, Salameh P. Impact of pharmacist-led interventions on patient care in ambulatory care settings: A systematic review. Int J Clin Pract. 2021 Nov;75(11):e14864. doi: 10.1111/ijcp.14864.
  2. Breuker C, Guedj AM, Allan M, Coinus L, Molinari N, Chapet N, Roubille F, Le Quintrec M, Duhalde V, Jouglen J, Cestac P, Kinowski JM, Faure S, Faucanie M, Lohan L, Villiet M, Altwegg R, Sultan A. The COVID-19 Pandemic Led to a Small Increase in Changed Mentality Regarding Infection Risk without Any Change in Willingness to Be Vaccinated in Chronic Diseases Patients. J Clin Med. 2021 Sep 1;10(17):3967. doi: 10.3390/jcm10173967.
  3. Eyvrard F, Metivier S, Sorli SC, Cabrit L, Jullien A, Cestac P. Financement des antiviraux d’action directe de l’hépatite C en psychiatrie [Funding of direct acting antivirals for hepatitis C in psychiatry setting]. Encephale. 2021 Dec;47(6):618-619. . doi: 10.1016/j.encep.2020.11.001.
  4. Mangé AS, Pagès A, Sourdet S, Cestac P, McCambridge C. Diabetes and Frail Older Patients: Glycemic Control and Prescription Profile in Real Life. Pharmacy (Basel). 2021 Jun 22;9(3):115. doi: 10.3390/pharmacy9030115.
  5. Pagès A, Rouch L, Costa N, Cestac P, De Souto Barreto P, Rolland Y, Vellas B, Molinier L, Juillard-Condat B, Mapt/Dsa Group. Potentially Inappropriate Medication Prescribing Detected by Computer Algorithm among Older Patients: Results from the MAPT Study. Pharmacy (Basel). 2021 Nov 24;9(4):189. doi: 10.3390/pharmacy9040189.
  6. Rouch L, Vidal JS, Hoang T, Cestac P, Hanon O, Yaffe K. Author Response: Systolic Blood Pressure Postural Changes Variability is Associated With Greater Dementia Risk. Neurology. 2021 Aug 17;97(7):349. doi: 10.1212/WNL.0000000000012432.
  7. Rouch L, De Souto Barreto P, Hanon O, Vidal JS, Amar J, Andrieu S, Cestac P, Rolland Y, Vellas B; MAPT/DSA Group. Visit-to-Visit Blood Pressure Variability and Incident Frailty in Older Adults. J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):1369-1375. doi: 10.1093/gerona/glab112.


  1. Pagès A, Mazon M, Cool C, McCambridge C, Cestac P, Rouch L, Juillard-Condat B. Cost analysis of potentially inappropriate medication in older hospitalized patients. Expert Rev Pharmacoecon Outcomes Res. 2020 Dec;20(6):623-627. doi: 10.1080/14737167.2020.1678384.
  2. Pagès A, Roland C, Qassemi S, Abdeljalil AB, Houles M, Romain M, Toulza O, Belloc A, McCambridge C, Voisin T, Cestac P, Juillard-Condat B; PharMoG study group. Impact of a Pharmacist-included Mobile Geriatrics team intervention on potentially inappropriate drug prescribing: protocol for a prospective feasibility study (PharMoG study). BMJ Open. 2020 Dec 2;10(12):e040917. doi: 10.1136/bmjopen-2020-040917.
  3. Qassemi S, Pagès A, Rouch L, Bismuth S, Stillmunkes A, Lapeyre-Mestre M, McCambridge C, Cool C, Cestac P. Potentially Inappropriate Drug Prescribing in French Nursing Home Residents: An Observational Study. Pharmacy (Basel). 2020 Jul 30;8(3):E133. doi :10.3390/pharmacy8030133.
  4. Rouch L, Cestac P, Sallerin B, Piccoli M, Benattar-Zibi L, Bertin P, Berrut G, Corruble E, Derumeaux G, Falissard B, Forette F, Pasquier F, Pinget M, Ourabah R, Danchin N, Hanon O, Vidal JS; S.AGES investigators. Visit-to-Visit Blood Pressure Variability Is Associated With Cognitive Decline and Incident Dementia: The S.AGES Cohort. Hypertension. 2020 Oct;76(4):1280-1288. doi: 10.1161/HYPERTENSIONAHA.119.14553.
  5. Rouch L, Vidal JS, Hoang T, Cestac P, Hanon O, Yaffe K. Systolic blood pressure postural changes variability is associated with greater dementia risk. Neurology. 2020 Oct 6;95(14):e1932-e1940.doi: 10.1212/WNL.0000000000010420.


  1. Maltais M, Rolland Y, Vellas B, Haÿ PE, Armaingaud D, Cestac P, Rouch L, Cesari M, de Souto Barreto P.  Effect of Exercise on Behavioral Symptoms and Pain in Patients With Dementia Living in Nursing Homes. Am J Alzheimers Dis Other Demen. 2019 Mar;34(2):89-94. doi: 10.1177/1533317518803773.
  2. Pagès A, Mazon M, Cool C, McCambridge C, Cestac P, Rouch L, Juillard-Condat B. Cost analysis of potentially inappropriate medication in older hospitalized patients. Expert Rev Pharmacoecon Outcomes Res. 2019 Oct 15:1-5. doi: 10.1080/14737167.2020.1678384.
  3. Rouch L, Cestac P, Hanon O, Ruidavets JB, Ehlinger V, Gentil C, Cool C, Helmer C, Dartigues JF, Bouhanick B, Chamontin B, Sallerin B, Vellas B, Marquié JC, Esquirol Y, Andrieu S.  Blood pressure and cognitive performances in middle-aged adults: the Aging, Health and Work longitudinal study. J Hypertens. 2019 Jun;37(6):1244-125 doi: 10.1097/HJH.0000000000002013.