MAINTAIN - MAintain Functions and INTrinsec capacities with Aging :
Preventive and personalized INterventional Research

Equipe constitutive du CERPOP, UMR 1295, unité mixte INSERM - Université Toulouse III Paul Sabatier
Nicola COLEY •  chercheure


  1. Aggarwal G, Morley JE, Vellas B, Nguyen AD, Butler AA; MAPT/DSA Group (Coley N collaborator). Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults. Geroscience. 2023 May 26. doi: 10.1007/s11357-023-00824-3. Epub ahead of print.
  2. Bencivenga L, Strumia M, Rolland Y, Martinez L, Cestac P, Guyonnet S, Andrieu S, Parini A, Lucas A, Vellas B, De Souto Barreto P, Rouch L; MAPT/D. S. A. group (Coley N collaborator). Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability. Geroscience. 2023 Apr;45(2):797-809. doi: 10.1007/s11357-022-00697-y.
  3. Giudici KV, de Souto Barreto P, Guyonnet S, Morley JE, Nguyen AD, Aggarwal G, Parini A, Li Y, Bateman RJ, Vellas B; MAPT/DSA Group (Coley N collaborator). TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study. J Gerontol A Biol Sci Med Sci. 2023 Mar 30;78(4):569-578. doi: 10.1093/gerona/glac244.
  4. Gonzalez-Bautista E, de Souto Barreto P, Salinas-Rodriguez A, Manrique-Espinoza B, Sourdet S, Rolland Y, Rodríguez-Mañas L, Andrieu S, Vellas B; MAPT/DSA Group (Coley N collaborator). Development and Validation of a Cutoff for the Chair Stand Test as a Screening for Mobility Impairment in the Context of the Integrated Care for Older People Program. J Gerontol A Biol Sci Med Sci. 2023 Jan 26;78(1):104-110. doi: 10.1093/gerona/glac055.
  5. Perus L, Mangin JF, Deverdun J, Gutierrez LA, Gourieux E, Fischer C, Van Dokkum LEH, Manesco C, Busto G, Guyonnet S, Vellas B, Gabelle A, Le Bars E; MAPT/DSA group (Coley N collaborator). Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study. Front Aging Neurosci. 2023 Jan 10;14:971220. doi: 10.3389/fnagi.2022.971220.
  6. Raffin J, Rolland Y, Parini A, Lucas A, Guyonnet S, Vellas B, de Souto Barreto P; MAPT/DSA Group (Coley N collaborator). Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis. J Cachexia Sarcopenia Muscle. 2023 Jan 20;14(2):771–80. doi: 10.1002/jcsm.13152. Epub ahead of print.


  1. Belleville S, Cloutier S, Mellah S, Willis S, Vellas B, Andrieu S, Coley N, Ngandu T; MAPT/DSA group. Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia. Alzheimers Dement. 2022 Nov;18(11):2140-2150. doi: 10.1002/alz.12544.
  2. Belleville S, Cloutier S, Mellah S, Vellas B, Andrieu S, Coley N, Ngandu T. Response to "Upping the dose of dementia risk reduction". Alzheimers Dement. 2022 Sep;18(9):1700-1701. doi: 10.1002/alz.12693.
  3. Bérard E, Huo Yung Kai S, Coley N, Bongard V, Ferrières J. One-Year Impact of COVID-19 Lockdown-Related Factors on Cardiovascular Risk and Mental Health: A Population-Based Cohort Study. Int J Environ Res Public Health. 2022 Feb 1;19(3):1684. doi: 10.3390/ijerph19031684.
  4. Coley N, Andre L, Hoevenaar-Blom MP, Ngandu T, Beishuizen C, Barbera M, van Wanrooij L, Kivipelto M, Soininen H, van Gool W, Brayne C, Moll van Charante E, Richard E, Andrieu S; HATICE study group; PRODEMOS study group. Factors Predicting Engagement of Older Adults With a Coach-Supported eHealth Intervention Promoting Lifestyle Change and Associations Between Engagement and Changes in Cardiovascular and Dementia Risk: Secondary Analysis of an 18-Month Multinational Randomized Controlled Trial. J Med Internet Res. 2022 May 9;24(5):e32006. doi: 10.2196/32006.
  5. Coley N, Giulioli C, Aisen PS, Vellas B, Andrieu S. Randomised controlled trials for the prevention of cognitive decline or dementia: A systematic review. Ageing Res Rev. 2022 Dec;82:101777. doi: 10.1016/j.arr.2022.101777.
  6. den Brok MGHE, Hoevenaar-Blom MP, Coley N, Andrieu S, van Dalen J, Meiller Y, Guillemont J, Brayne C, van Gool WA, Moll van Charante EP, Richard E. The Effect of Multidomain Interventions on Global Cognition, Symptoms of Depression and Apathy - A Pooled Analysis of Two Randomized Controlled Trials. J Prev Alzheimers Dis. 2022;9(1):96-103. doi: 10.14283/jpad.2021.53.
  7. Eggink E, Hafdi M, Hoevenaar-Blom MP, Richard E, Moll van Charante EP; PRODEMOS-consortium (Andrieu S, Coley N collaborator). Attitudes and views on healthy lifestyle interventions for the prevention of dementia and cardiovascular disease among older people with low socioeconomic status: a qualitative study in the Netherlands. BMJ Open. 2022 Feb 28;12(2):e055984. doi: 10.1136/bmjopen-2021-055984.
  8. Lu WH, Giudici KV, Morley JE, Guyonnet S, Parini A, Aggarwal G, Nguyen AD, Li Y, Bateman RJ, Vellas B, de Souto Barreto P; MAPT/DSA Group (Coley N collaborators). Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults. Geroscience. 2022 Jun;44(3):1489-1503. doi: 10.1007/s11357-022-00554-y.
  9. Molet-Benhamou L, Giudici KV, de Souto Barreto P, Cantet C, Rolland Y; MAPT/DSA group (Coley N collaborator). Association between urate-lowering therapies and cognitive decline in community-dwelling older adults. Sci Rep. 2022 Sep 12;12(1):15299. doi: 10.1038/s41598-022-17808-6.
  10. Mura T, Coley N, Amieva H, Berr C, Gabelle A, Ousset PJ, Vellas B, Andrieu S; GuidAge/DSA study group*. Cognitive decline as an outcome and marker of progression toward dementia, in early preventive trials. Alzheimers Dement. 2022 Apr;18(4):676-687. doi: 10.1002/alz.12431.
  11. Pagès A, Costa N, Mounié M, Cestac P, De Souto Barreto P, Rolland Y, Vellas B, Molinier L, Juillard-Condat B; MAPT/DSA Group (Andrieu S, Cantet C, Coley N collaborators). Healthcare Costs Associated with Potentially Inappropriate Medication Prescribing Detected by Computer Algorithm Among Older Patients. Drugs Aging. 2022 May;39(5):367-375. doi: 10.1007/s40266-022-00938-x.
  12. Raffin J, Angioni D, Giudici KV, Valet P, Aggarwal G, Nguyen AD, Morley JE, Guyonnet S, Rolland Y, Vellas B, de Souto Barreto P; MAPT/DSA Group (Andrieu S, Cantet C, Coley N collaborators) . Physical Activity, Body Mass Index, and Blood Progranulin in Older Adults: Cross-Sectional Associations in the MAPT Study. J Gerontol A Biol Sci Med Sci. 2022 Jun 1;77(6):1141-1149. doi: 10.1093/gerona/glac018.
  13. Sanchez-Sanchez JL, Giudici KV, Guyonnet S, Delrieu J, Li Y, Bateman RJ, Parini A, Vellas B, de Souto Barreto P; MAPT/DSA Group (Coley N collaborator). Plasma MCP-1 and changes on cognitive function in community-dwelling older adults. Alzheimers Res Ther. 2022 Jan 7;14(1):5. doi: 10.1186/s13195-021-00940-2.
  14. Sindi S, Thunborg C, Rosenberg A, Andersen P, Andrieu S, Broersen LM, Coley N, Couderc C, Duval CZ, Faxen-Irving G, Hagman G, Hallikainen M, Håkansson K, Lehtisalo J, Levak N, Mangialasche F, Pantel J, Kekkonen E, Rydström A, Stigsdotter-Neely A, Wimo A, Ngandu T, Soininen H, Hartmann T, Solomon A, Kivipelto M. Multimodal Preventive Trial for Alzheimer's Disease: MIND-ADmini Pilot Trial Study Design and Progress. J Prev Alzheimers Dis. 2022;9(1):30-39. doi: 10.14283/jpad.2022.4.


  1. Coley N, Coniasse-Brioude D, Igier V, Fournier T, Poulain JP, Andrieu S; ACCEPT study group. Disparities in the participation and adherence of older adults in lifestyle-based multidomain dementia prevention and the motivational role of perceived disease risk and intervention benefits: an observational ancillary study to a randomised controlled trial. Alzheimers Res Ther. 2021 Sep 24;13(1):157. doi: 10.1186/s13195-021-00904-6.
  2. Eggink E, Hafdi M, Hoevenaar-Blom MP, Song M, Andrieu S, Barnes LE, Birck C, Brooks RL, Coley N, Ford E, Georges J, van der Groep A, van Gool WA, Handels R, Hou H, Li D, Liu H, Lyu J, van Marwijk H, van der Meijden M, Niu Y, Sadhwani S, Wang W, Wang Y, Wimo A, Ye X, Yu Y, Zeng Q, Zhang W, Wang W, Brayne C, Moll van Charante EP, Richard E. Prevention of dementia using mobile phone applications (PRODEMOS): protocol for an international randomised controlled trial. BMJ Open. 2021 Jun 9;11(6):e049762. doi: 10.1136/bmjopen-2021-049762.
  3. Guerville F, De Souto Barreto P, Coley N, Andrieu S, Mangin JF, Chupin M, Payoux P, Ousset PJ, Rolland Y, Vellas B; MAPT/DSA group. Kidney Function and Cognitive Decline in Older Adults: Examining the Role of Neurodegeneration. J Am Geriatr Soc. 2021 Mar;69(3):651-659. doi: 10.1111/jgs.16954.
  4. Hafdi M, Eggink E, Hoevenaar-Blom MP, Witvliet MP, Andrieu S, Barnes L, Brayne C, Brooks R, Coley N, Georges J, van der Groep A, van Marwijk H, van der Meijden M, Song L, Song M, Wang Y, Wang W, Wang W, Wimo A, Ye X, van Charante EPM, Richard E. Design and Development of a Mobile Health (mHealth) Platform for Dementia Prevention in the Prevention of Dementia by Mobile Phone Applications (PRODEMOS) Project. Front Neurol. 2021 Dec 16;12:733878. doi: 10.3389/fneur.2021.733878.
  5. He L, Morley JE, Aggarwal G, Nguyen AD, Vellas B, de Souto Barreto P; MAPT/DSA Group (Coley N collaborator). Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults. Sci Rep. 2021 Jun 28;11(1):13394. doi: 10.1038/s41598-021-91038-0.
  6. Ngandu T, Lehtisalo J, Korkki S, Solomon A, Coley N, Antikainen R, Bäckman L, Hänninen T, Lindström J, Laatikainen T, Paajanen T, Havulinna S, Peltonen M, Neely AS, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER). Alzheimers Dement. 2021 Oct 20. doi: 10.1002/alz.12492. Epub ahead of print.
  7. Raffin J, Rolland Y, Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, Vellas B, Barreto PS; MAPT/DSA Group (Coley N collaborator). Associations Between Physical Activity, Blood-Based Biomarkers of Neurodegeneration, and Cognition in Healthy Older Adults: The MAPT Study. J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):1382-1390. doi: 10.1093/gerona/glab094.
  8. Takano E, Maltais M, Kondo I, Rolland Y; MAPT/DSA group (Coley A collaborator). Bidirectional relationship between depressive symptoms and physical performance in community-dwelling older people with subjective memory complaints. Eur Geriatr Med. 2021 Oct;12(5):973-980. . doi: 10.1007/s41999-021-00473-9.


  1. Akenine U, Barbera M, Beishuizen CR, Fallah Pour M, Guillemont J, Rosenberg A, Coley N, Mangialasche F, Salo L, Savy S, Pols AJ, Andrieu S, Richard E, Soininen H, Moll van Charante E, Kivipelto M; HATICE study group. Attitudes of at-risk older adults about prevention of cardiovascular disease and dementia using eHealth: a qualitative study in a European context. BMJ Open. 2020 Aug 6;10(8):e037050. doi: 10.1136/bmjopen-2020-037050.
  2. Bérard E, Huo Yung Kai S, Coley N, Bongard V, Ferrières J. Lockdown-related factors associated with the worsening of cardiovascular risk and anxiety or depression during the COVID-19 pandemic. Prev Med Rep. 2020 Dec 28;21:101300. doi: 10.1016/j.pmedr.2020.101300.
  3. Coley N, Hoevenaar-Blom MP, van Dalen JW, Moll van Charante EP, Kivipelto M, Soininen H, Andrieu S, Richard E; PRODEMOS consortium, the preDIVA study group, the MAPT/DSA group, and the HATICE consortium. Dementia risk scores as surrogate outcomes for lifestyle-based multidomain prevention trials-rationale, preliminary evidence and challenges. Alzheimers Dement. 2020 Dec;16(12):1674-1685.doi: 10.1002/alz.12169.
  4. He L, de Souto Barreto P, Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, Vellas B; MAPT/DSA Group (Coley N collaborator). Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults. Alzheimers Res Ther. 2020 Oct 8;12(1):128. doi: 10.1186/s13195-020-00697-0.
  5. Rosenberg A, Coley N, Soulier A, Kulmala J, Soininen H, Andrieu S, Kivipelto M, Barbera M, MIND-AD and HATICE groups. Experiences of dementia and attitude towards prevention: a qualitative study among older adults participating in a prevention trial. BMC Geriatr. 2020 Mar 12;20(1):99.doi: 10.1186/s12877-020-1493-4.
  6. Soriano G, De Souto Barreto P, Virecoulon Giudici K, Cantet C , Guyonnet S, Vellas B , Rolland Y , Andrieu S , MAPT DSA Study Group (Coley N collaborator). Meal-related difficulties and weight loss in older people: Longitudinal data from MAPT study. Clin Nutr. 2020 Nov;39(11):3483-3488. doi: 10.1016/j.clnu.2020.03.011.
  7. van Wanrooij LL, Hoevenaar-Blom MP, Coley N, Ngandu T, Meiller Y, Guillemont J, Rosenberg A, Beishuizen CRL, Moll van Charante EP, Soininen H, Brayne C, Andrieu S, Kivipelto M, Richard E. Pooling individual participant data from randomized controlled trials: Exploring potential loss of information. PLoS One. 2020 May 12;15(5):e0232970. doi:10.1371/journal.pone.0232970.
  8. Hooper C, Coley N, De Souto Barreto P, Payoux P, Salabert AS, Andrieu S, Weiner M, Vellas B. Cortical β-Amyloid in Older Adults Is Associated with Multidomain Interventions with and without Omega 3 Polyunsaturated Fatty Acid Supplementation. J Prev Alzheimers Dis. 2020;7(2):128–134. doi: 10.14283/jpad.2020.4.


  1. André L, Gallini A, Montastruc F, Coley N, Montastruc JL, Vellas B, Andrieu S, Gardette V; MAPT/DSA study group. Anticholinergic exposure and cognitive decline in older adults: effect of anticholinergic exposure definitions in a 3-year analysis of the multidomain Alzheimer preventive trial (MAPT) study. Br J Clin Pharmacol. 2019 Jan;85(1):71-99. doi: 10.1111/bcp.13734.
  2. Coley N, Ngandu T, Lehtisalo J, Soininen H, Vellas B, Richard E, Kivipelto M, Andrieu S; HATICE, FINGER, and MAPT/DSA groups. Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials. Alzheimers Dement. 2019 Jun;15(6):729-741. doi: 10.1016/j.jalz.2019.03.005.
  3. Coley N, Rosenberg A, van Middelaar T, Soulier A, Barbera M, Guillemont J, Steensma J, Igier V, Eskelinen M, Soininen H, Moll van Charante E, Richard E, Kivipelto M, Andrieu S; MIND-AD; HATICE groups. Older Adults' Reasons for Participating in an eHealth Prevention Trial: A Cross-Country, Mixed-Methods Comparison. J Am Med Dir Assoc. 2019 Jul;20(7):843-849.e5. doi: 10.1016/j.jamda.2018.10.019.
  4. Gabelle A, Jaussent I, Bouallègue FB, Lehmann S, Lopez R, Barateau L, Grasselli C, Pesenti C, de Verbizier D, Béziat S, Mariano-Goulart D, Carlander B, Dauvilliers Y; Alzheimer's Disease Neuroimaging Initiative; Multi-Domain Intervention Alzheimer's Prevention Trial study groups. (Coley N collaborator). Reduced brain amyloid burden in elderly patients with narcolepsy type 1. Ann Neurol. 2019 Jan;85(1):74-83. doi: 10.1002/ana.25373.
  5. Vermunt L, Sikkes SAM, van den Hout A, Handels R, Bos I, van der Flier WM, Kern S, Ousset PJ, Maruff P, Skoog I, Verhey FRJ, Freund-Levi Y, Tsolaki M, Wallin ÅK, Olde Rikkert M, Soininen H, Spiru L, Zetterberg H, Blennow K, Scheltens P, Muniz-Terrera G, Visser PJ; Alzheimer Disease Neuroimaging Initiative; AIBL Research Group; ICTUS/DSA study groups (Coley N collaborator). Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype. Alzheimers Dement. 2019. 15(7):888-898. doi: 10.1016/j.jalz.2019.04.001.