MAINTAIN - MAintain Functions and INTrinsec capacities with Aging :
Preventive and personalized INterventional Research

Equipe constitutive du CERPOP, UMR 1295, unité mixte INSERM - Université Toulouse III Paul Sabatier
DELRIEU Julien • Doctorant



2024

  1. Aggarwal G, Morley JE, Vellas B, Nguyen AD, Butler AA (Delrieu J, Coley N collaborators) ; MAPT/DSA Group. Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults. Geroscience. 2024. 46(1):897-91 doi: 10.1007/s11357-023-00824-3.
  2. Angioni D, Delrieu J, Coley N, Ousset PJ, Shi J, Vellas B. Drugs for Alzheimer's disease: Where are we coming from? Where are we going? Sci Bull (Beijing). 2024. 69(10):1369-1374. doi: 10.1016/j.scib.2024.02.02
  3. Blivet G, Roman FJ, Delrieu J, Touchon J. Translation from Preclinical Research to Clinical Trials: Brain-Gut Photobiomodulation Therapy for Alzheimer's Disease. J Integr Neurosci. 2024 Mar 11;23(3):57. doi: 10.31083/j.jin2303057.
  4. Coley N, Zetterberg H, Cantet C, Guyonnet S, Ashton NJ, Vellas B, Blennow K, Andrieu S; MAPT study group (Abellan Van Kan G, Delrieu J. collaborators). Plasma p-tau181 as an outcome and predictor of multidomain intervention effects: a secondary analysis of a randomised, controlled, dementia prevention trial. Lancet Healthy Longev. 2024. 5(2):e120-e130. doi: 10.1016/S2666-7568(23)00255-6.
  5. Delrieu J, Andrieu S, Vellas B. Dementia research in 2023: the year of anti-amyloid immunotherapy. Lancet Neurol. 20223(1):13-15. doi: 10.1016/S1474-4422(23)00449-0.
  6. Gallet Q, Bouteloup V, Locatelli M, Habert MO, Chupin M, Campion JY, Michels PE, Delrieu J, Lebouvier T, Balageas AC, Surget A, Belzung C, Arlicot N, Ribeiro MS, Gissot V, El-Hage W, Camus V, Gohier B, Desmidt T; MEMENTO study group. Cerebral Metabolic Signature of Chronic Benzodiazepine Use in Nondemented Older Adults: An FDG-PET Study in the MEMENTO Cohort. Am J Geriatr Psychiatry. 2024 Jun;32(6):665-677. doi: 10.1016/j.jagp.2023.10.002.
  7. Lengelé L, Rolland Y, Martinez LO, Guyonnet S, Parini A, Lucas A, Vellas B, Barreto PS; MAPT/DSA Group (Coley N, Delrieu J collaborators). Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study. J Gerontol A Biol Sci Med Sci. 2024. 79(1):glad236. doi: 10.1093/gerona/glad236.
  8. Tremblay-Franco M, Canlet C, Carriere A, Nakhle J, Galinier A, Portais JC, Yart A, Dray C, Lu WH, Bertrand Michel J, Guyonnet S, Rolland Y, Vellas B, Delrieu J, Barreto PS, Pénicaud L, Casteilla L, Ader I; MAPT/DSA Group. Integrative Multimodal Metabolomics to Early Predict Cognitive Decline Among Amyloid Positive Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2024. 79(5):glae077. doi: 10.1093/gerona/glae077.


2022

2022

  1. Altomare D, Collij L, Caprioglio C, Scheltens P, van Berckel BNM, Alves IL, Berkhof J, de Gier Y, Garibotto V, Moro C, Poitrine L, Delrieu J, Payoux P, Saint-Aubert L, Molinuevo JL, Grau-Rivera O, Gispert JD, Minguillón C, Fauria K, Sanchez MF, Rădoi A, Drzezga A, Jessen F, Escher C, Zeyen P, Nordberg A, Savitcheva I, Jelic V, Walker Z, Lee HY, Lee L, Demonet JF, Plaza Wuthrich S, Gismondi R, Farrar G, Barkhof F, Stephens AW, Frisoni GB; AMYPAD Consortium. Description of a European memory clinic cohort undergoing amyloid-PET: The AMYPAD Diagnostic and Patient Management Study. Alzheimers Dement. 2022 Jun 17. doi: 10.1002/alz.12696. Epub ahead of print.
     
  2. Angioni D, Delrieu J, Hansson O, Fillit H, Aisen P, Cummings J, Sims JR, Braunstein JB, Sabbagh M, Bittner T, Pontecorvo M, Bozeat S, Dage JL, Largent E, Mattke S, Correa O, Gutierrez Robledo LM, Baldivieso V, Willis DR, Atri A, Bateman RJ, Ousset PJ, Vellas B, Weiner M. Blood Biomarkers from Research Use to Clinical Practice: What Must Be Done? A Report from the EU/US CTAD Task Force. J Prev Alzheimers Dis. 2022;9(4):569-579. doi: 10.14283/jpad.2022.85.
     
  3. Bencivenga L, Strumia M, Rolland Y, Martinez L, Cestac P, Guyonnet S, Andrieu S, Parini A, Lucas A, Vellas B, De Souto Barreto P, Rouch L; MAPT/D. S. A. group (Delrieu J collaborator). Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability. Geroscience. 2022 Dec 1. doi: 10.1007/s11357-022-00697-y. Epub ahead of print.
     
  4. Delrieu J, Bateman RJ, Touchon J, Sabbagh M, Cummings J. The Future of AD Clinical Trials with the Advent of Anti-Amyloid Therapies: An CTAD Task Force Report. J Prev Alzheimers Dis. 2022;9(3):393-399. doi: 10.14283/jpad.2022.48.
     
  5. Gallet Q, Bouteloup V, Locatelli M, Habert MO, Chupin M, Delrieu J, Lebouvier T, Robert G, David R, Bulteau S, Balageas AC, Surget A, Belzung C, Arlicot N, Ribeiro MJ, Barantin L, Andersson F, Cottier JP, Gissot V, El-Hage W, Camus V, Gohier B, Desmidt T; MEMENTO study group. Benzodiazepine use and neuroimaging markers of Alzheimer's disease in nondemented older individuals: an MRI and 18F Florbetapir PET study in the MEMENTO cohort. Neuropsychopharmacology. 2022 Apr;47(5):1114-1120. doi: 10.1038/s41386-021-01246-5.
     
  6. Lu WH, Giudici KV, Morley JE, Guyonnet S, Parini A, Aggarwal G, Nguyen AD, Li Y, Bateman RJ, Vellas B, de Souto Barreto P; MAPT/DSA Group (Delrieu J collaborator). Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults. Geroscience. 2022 Apr 20. doi: 10.1007/s11357-022-00554-y. Epub ahead of print.
     
  7. Molet-Benhamou L, Giudici KV, de Souto Barreto P, Cantet C, Rolland Y; MAPT/DSA group (Delrieu J collaborator). Association between urate-lowering therapies and cognitive decline in community-dwelling older adults. Sci Rep. 2022 Sep 12;12(1):15299. doi: 10.1038/s41598-022-17808-6.
     
  8. Pagès A, Costa N, Mounié M, Cestac P, De Souto Barreto P, Rolland Y, Vellas B, Molinier L, Juillard-Condat B; MAPT/DSA Group (Delrieu J collaborator). Healthcare Costs Associated with Potentially Inappropriate Medication Prescribing Detected by Computer Algorithm Among Older Patients. Drugs Aging. 2022 May;39(5):367-375. doi: 10.1007/s40266-022-00938-x.
     
  9. Raffin J, Angioni D, Giudici KV, Valet P, Aggarwal G, Nguyen AD, Morley JE, Guyonnet S, Rolland Y, Vellas B, de Souto Barreto P; MAPT/DSA Group (Delrieu J collaborator). Physical Activity, Body Mass Index, and Blood Progranulin in Older Adults: Cross-Sectional Associations in the MAPT Study. J Gerontol A Biol Sci Med Sci. 2022 Jun 1;77(6):1141-1149. doi: 10.1093/gerona/glac018.
     
  10. Rouch L, Virecoulon Giudici K, Cantet C, Guyonnet S, Delrieu J, Legrand P, Catheline D, Andrieu S, Weiner M, de Souto Barreto P, Vellas B; Alzheimer's Disease Neuroimaging Initiative. Associations of erythrocyte omega-3 fatty acids with cognition, brain imaging and biomarkers in the Alzheimer's disease neuroimaging initiative: cross-sectional and longitudinal retrospective analyses. Am J Clin Nutr. 2022 Oct 17:nqac236. doi: 10.1093/ajcn/nqac236. Epub ahead of print.
     
  11. Sanchez-Sanchez JL, Giudici KV, Guyonnet S, Delrieu J, Li Y, Bateman RJ, Parini A, Vellas B, de Souto Barreto P; MAPT/DSA Group. Plasma MCP-1 and changes on cognitive function in community-dwelling older adults. Alzheimers Res Ther. 2022 Jan 7;14(1):5. doi: 10.1186/s13195-021-00940-2.

2021

  1. De Mauleon A, Delrieu J, Cantet C, Vellas B, Andrieu S, Rosenberg PB, Lyketsos CG, Soto Martin M. Longitudinal Course of Agitation and Aggression in Patients with Alzheimer's Disease in a Cohort Study: Methods, Baseline and Longitudinal Results of the A3C Study. J Prev Alzheimers Dis. 2021;8(2):199-209. doi: 10.14283/jpad.2020.66.
     
  2. Fougère B, Daumas M, Lilamand M, Sourdet S, Delrieu J, Vellas B, Abellan van Kan G. RETRACTED: Association Between Frailty and Cognitive Impairment: Cross-Sectional Data From Toulouse Frailty Day Hospital. J Am Med Dir Assoc. 2021 Jul;22(7):1564. doi: 10.1016/j.jamda.2021.06.004. Epub 2021 Jun 8. Erratum for: J Am Med Dir Assoc. 2017 Nov 1;18(11):990.e1-990.e5.
     
  3. He L, de Souto Barreto P, Giudici KV, Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, Vellas B; MAPT/DSA Group (Delrieu J collaborator). Cross-Sectional and Longitudinal Associations Between Plasma Neurodegenerative Biomarkers and Physical Performance Among Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1874-1881. doi: 10.1093/gerona/glaa284.
     
  4. He L, Morley JE, Aggarwal G, Nguyen AD, Vellas B, de Souto Barreto P; MAPT/DSA Group (Delrieu J collaborator). Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults. Sci Rep. 2021 Jun 28;11(1):13394. doi: 10.1038/s41598-021-91038-0.
     
  5. Lafaurie M, Martin-Blondel G, Delobel P, Kamar N, Charpentier S, Sommet A, Moulis G; Covid-Clinic-Toul investigators (Delrieu J collaborator). Impact of previous exposure to systemic corticosteroids on unfavorable outcome in patients hospitalized for COVID-19. BMC Pharmacol Toxicol. 2021 Mar 11;22(1):14. doi: 10.1186/s40360-021-00480-3.
     
  6. Lu WH, de Souto Barreto P, Rolland Y, Bouyahia A, Fischer C, Mangin JF, Giudici KV, Vellas B; MAPT/DSA Group (Delrieu J collaborator). Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study. J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):e361-e369. doi: 10.1093/gerona/glaa296.
     
  7. Raffin J, Rolland Y, Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, Vellas B, Barreto PS; MAPT/DSA Group (Delrieu J collaborator). Associations Between Physical Activity, Blood-Based Biomarkers of Neurodegeneration, and Cognition in Healthy Older Adults: The MAPT Study. J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):1382-1390. doi: 10.1093/gerona/glab094.
     
  8. Rouch L, De Souto Barreto P, Hanon O, Vidal JS, Amar J, Andrieu S, Cestac P, Rolland Y, Vellas B; MAPT/DSA Group (Delrieu J collaborator). Visit-to-Visit Blood Pressure Variability and Incident Frailty in Older Adults. J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):1369-1375. doi: 10.1093/gerona/glab112.
     
  9. Takano E, Maltais M, Kondo I, Rolland Y; MAPT/DSA group (Delrieu J collaborator). Bidirectional relationship between depressive symptoms and physical performance in community-dwelling older people with subjective memory complaints. Eur Geriatr Med. 2021 Oct;12(5):973-980. doi: 10.1007/s41999-021-00473-9. . doi: 10.1007/s41999-021-00473-9.
     
  10. Tavassoli N, Piau A, Berbon C, De Kerimel J, Lafont C, De Souto Barreto P, Guyonnet S, Takeda C, Carrie I, Angioni D, Paris F, Mathieu C, Ousset PJ, Balardy L, Voisin T, Sourdet S, Delrieu J, Bezombes V, Pons-Pretre V, Andrieu S, Nourhashemi F, Rolland Y, Soto ME, Beard J, Sumi Y, Araujo Carvalho I, Vellas B. Framework Implementation of the INSPIRE ICOPE-CARE Program in Collaboration with the World Health Organization (WHO) in the Occitania Region. J Frailty Aging. 2021;10(2):103-109. doi: 10.14283/jfa.2020.26.
2020
  1. Angioni D, Macaron T, Takeda C, Sourdet S, Cesari M, Virecoulon Giudici K, Raffin J, Lu WH, Delrieu J, Touchon J, Rolland Y, de Souto Barreto P, Vellas B. Can We Distinguish Age-Related Frailty from Frailty Related to Diseases ? Data from the MAPT Study. J Nutr Health Aging. 2020;24(10):1144-1151. doi: 10.1007/s12603-020-1518-x.
  2. Delrieu J, Voisin T, Saint-Aubert L, Carrie I, Cantet C, Vellas B, Payoux P, Andrieu S. The impact of a multi-domain intervention on cerebral glucose metabolism: analysis from the randomized ancillary FDG PET MAPT trial. Alzheimers Res Ther. 2020 Oct 19;12(1):134. doi: 10.1186/s13195-020-00683-6.
  3. Frisoni GB, Molinuevo JL, Altomare D, Carrera E, Barkhof F, Berkhof J, Delrieu J, Dubois B, Kivipelto M, Nordberg A, Schott JM, van der Flier WM, Vellas B, Jessen F, Scheltens P, Ritchie C. Precision prevention of Alzheimer's and other dementias: Anticipating future needs in the control of risk factors and implementation of disease-modifying therapies. Alzheimers Dement. 2020 Oct;16(10):1457-1468. doi: 10.1002/alz.12132.
  4. Maltais M, de Souto Barreto P, Perus L, Mangin JF, Grigis A, Chupin M, Bouyahia A, Gabelle A, Delrieux J, Rolland Y, Vellas B. Re: Prospective Associations between Diffusion Tensor Imaging Parameters and Frailty in Older Adults [published online ahead of print, 2020 Apr 16]. J Am Geriatr Soc. 2020. doi:10.1111/jgs.1645.
  5. Maltais M, de Souto Barreto P, Perus L, Mangin JF, Grigis A, Chupin M, Bouyahia A, Gabelle A, Delrieux J, Rolland Y, Vellas B; Multidomain Alzheimer Preventive Trial/Data Sharing Alzheimer (MAPT/DSA) Study Group. Prospective Associations Between Diffusion Tensor Imaging Parameters and Frailty in Older Adults. J Am Geriatr Soc. 2020 May;68(5):1050-1055. doi: 10.1111/jgs.16343.
  6. Maltais M, de Souto Barreto P, Perus L, Mangin JF, Grigis A, Chupin M, Bouyahia A, Gabelle A, Delrieux J, Rolland Y, Vellas B. Re: Prospective Associations between Diffusion Tensor Imaging Parameters and Frailty in Older Adults. J Am Geriatr Soc. 2020 Apr 16. doi: 10.1111/jgs.16456. Epub ahead of print.
  7. Maltais M, Rolland Y, Boisvert-Vigneault K, Perus L, Mangin JF, Grigis A, Chupin M, Bouyahia A, Gabelle A, Delrieux J, Vellas B, de Souto Barreto P.. Prospective associations between physical activity levels and white matter integrity in older adults: results from the MAPT study. Maturitas. 2020;137:24-29. doi: 10.1016/j.maturitas.2020.04.012.
2019
  1. Dietlin S, Soto M, Kiyasova V, Pueyo M, de Mauleon A, Delrieu J, Ousset PJ, Vellas B. Neuropsychiatric Symptoms and Risk of Progression to Alzheimer's Disease Among Mild Cognitive Impairment Subjects. J Alzheimers Dis. 2019. 70 (1), 25-34. doi  10.3233/JAD-190025.