SPHERE - Study of Perinatal, paediatric and adolescent Health : Epidemiological Research and Evaluation
Equipe constitutive du CERPOP, UMR1295, unité mixte de recherche Inserm – Université Toulouse III Paul Sabatier
Catherine ARNAUD •  chercheure, MD PHD, Santé publique, épidémiologie

  1. Alberge C, Ehlinger V, Noack N, Bolzoni C, Colombié B, Breinig S, Dicky O, Delobel M, Arnaud C. Early psychomotor therapy in very preterm infants does not improve Bayley-III scales at 2 years. Acta Paediatr. 2023 Sep;112(9):1916-1925. doi: 10.1111/apa.16848.
  2. Arnaud C, Ehlinger V, Perraud A, Kinsner-Ovaskainen A, Klapouszczak D, Himmelmann K, Petra M, Rackauskaite G, Lanzoni M, Platt MJ, Delobel-Ayoub M. Public health indicators for cerebral palsy: A European collaborative study of the Surveillance of Cerebral Palsy in Europe network. Paediatr Perinat Epidemiol. 2023 Feb 1. doi: 10.1111/ppe.12950. Epub ahead of print.
  3. Breinig S, Ehlinger V, Rozé JC, Storme L, Torchin H, Durrmeyer X, Cambonie G, Delacourt C, Jarreau PH, Berthomieu L, Brissaud O, Benhammou V, Gascoin G, Arnaud C, Ancel PY. Pulmonary hypertension among preterm infants born at 22 through 32 weeks gestation in France: Prevalence, survival, morbidity and management in the EPIPAGE-2 cohort study. Early Hum Dev. 2023 Sep;184:105837. doi: 10.1016/j.earlhumdev.2023.105837.
  4. Estublier B, Colineaux H, Arnaud C, Cintas P, Baudou E, Chaix Y, Rivier F, Biotteau M, Meyer P, Cheuret E. Long-term outcomes of paediatric Guillain-Barré syndrome. Dev Med Child Neurol. 2023 Jul 27. doi: 10.1111/dmcn.15693. Epub ahead of print.
  5. Gire C, Beltran Anzola A, Marret S, Foix L'Hélias L, Roze JC, Granier M, Patural H, Lecomte B, Guillois B, Souksi Medioni I, Bednarek Weirauch N, Claris O, Hascoët JM, Kuhn P, Zahed M, Boucekine M, Ancel PY, Arnaud C, Cambonie G, Dorriere Datin V; EPIREMED Study Group. Cognitive Training for Visuospatial Processing in Children Aged 5½ to 6 Years Born Very Preterm With Working Memory Dysfunction: A Randomized Clinical Trial. JAMA Netw Open. 2023 Sep 5;6(9):e2331988. doi: 10.1001/jamanetworkopen.2023.31988.
  6. Guyard A, Fauconnier J, Muehlan H, Cytera C, Markwart H, Himmelmann K, Schmidt S, Duffaut C, Arnaud C, Thyen U. Differences in participation between young adults with cerebral palsy and their peers: A cross-sectional multicentre European study. Disability and Health Journal Available online 29 November 2023, 101554. In Press. doi: 10.1016/j.dhjo.2023.101554
  7. Hoarau D, Tosello B, Blanc J, Lorthe E, Foix-L'Helias L, D'Ercole C, Winer N, Subtil D, Goffinet F, Kayem G, Resseguier N, Gire C; EPIPAGE2 Obstetric Writing Group* (Gascoin G, Vayssières C, Arnaud C collaborators). Chorionicity and neurodevelopmental outcomes at 5½ years among twins born preterm: the EPIPAGE2 cohort study. BJOG. 2023 Aug;130(9):1047-1058. doi: 10.1111/1471-0528.17460.
  8. Horber V, Andersen GL, Arnaud C, De La Cruz J, Dakovic I, Greitane A, Hensey O, Himmelmann K, Hollody K, Horridge K, Künzle CT, Marcelli M, Ortibus E, Papavasiliou A, Perra O, Platt MJ, Rackauskaite G, Sigurdardottir S, Gergeli AT, Virella D, Krägeloh-Mann I, Sellier E. Prevalence, Clinical Features, Neuroimaging, and Genetic Findings in Children With Ataxic Cerebral Palsy in Europe. Neurology. 2023 Oct 19:10.1212/WNL.0000000000207851. doi: 10.1212/WNL.0000000000207851. Epub ahead of print.
  9. Le Ray I, Kuhn P, Letouzey M, Roué JM, Mitha A, Glorieux I, Foix-L'Hélias L, Marchand-Martin L, Ancel PY, Kaminski M, Pierrat V; Epipage 2 Neurodevelopmental care writing Group; EPIPAGE-2 Infectious diseases writing group (Arnaud C collaborator). Early skin-to-skin contact and risk of late-onset-sepsis in very and extremely preterm infants. Pediatr Res. 2023 Jun;93(7):2091-2100. doi: 10.1038/s41390-022-02383-3.
  10. Perret, et coll. Assessing the Adequacy of the Physical, Social and Attitudinal Environment to the Specific Needs of Young Adults with Cerebral Palsy: the European Adult Environment Questionnaire Archives of Physical Medicine and Rehabilitation. 2023. In press.
  11. Pudig L, Delobel-Ayoub M, Horridge K, Gergeli AT, Sellier E, Ehlinger V, Hollody K, Virella D, Vik T, Arnaud C. Classification of events contributing to postneonatal cerebral palsy: Development, reliability, and recommendations for use. Dev Med Child Neurol. 2023 Jul 24. doi: 10.1111/dmcn.15710. Epub ahead of print.
  12. Simon L, Hadchouel A, Arnaud C, Frondas-Chauty A, Marret S, Flamant C, Darmaun D, Delacourt C, Marchand-Martin L, Ancel PY, Roze JC. Growth trajectory during the first 1000 days and later overweight in very preterm infants. Arch Dis Child Fetal Neonatal Ed. 2023 Mar;108(2):149-155. doi: 10.1136/archdischild-2022-324321.
  13. Thom EA, Saade GR, Askie LM, Ugwu LG, Mol BWJ, Vayssiere C, Norman JE, Pajkrt E, Clifton RG, Biggio JR, Arnaud C, Berghella V, Canino MG, Carreras E, Dugoff L, Hoffman MK, Pacagnella RC, Reddy UM, Saccone G, Hooft JV', Dang VQ; Prospective Meta-analysis for Pessary Trials Collaboration. PROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol. Am J Perinatol. 2023 Jul 10. doi: 10.1055/s-0043-1771018. Epub ahead of print.
  14. Thomas C, Timofeeva I, Bouchoucha E, Canceill T, Champion C, Groussolles M, Arnaud C, Vayssière C, Nabet C, Laurencin-Dalicieux S. Oral and periodontal assessment at the first trimester of pregnancy: The PERISCOPE longitudinal study. Acta Obstet Gynecol Scand. 2023 Jun;102(6):669-680. doi: 10.1111/aogs.14529.
  15. Vidart d'Egurbide Bagazgoïtia N, Perret C, Himmelmann K, Thyen U, Ehlinger V, Duffaut C, Arnaud C, Sentenac M. Employment and higher education in young adults with cerebral palsy: a cross-sectional analysis of the SPARCLE study. BMJ Public health. November 2023. doi:10.1136/bmjph-2023-000141
  16. Wallach E, Ehlinger V, Biotteau M, Walther-Louvier U, Péréon Y, Vuillerot C, Fontaine S, Sabouraud P, Espil-Taris C, Cuisset JM, Laugel V, Baudou E, Arnaud C, Cances C. Confirmatory validation of the french version of the Duchenne Muscular Dystrophy module of the pediatric quality of life inventory (PedsQLTM3.0DMDfv). BMC Pediatr. 2023 Nov 15;23(1):563. doi: 10.1186/s12887-023-04153-4.
2023 Publications cliniques
  1. Garnier A, Brochard K, Kwon T, Sellier-Leclerc AL, Lahoche A, Launay EA, Nobili F, Caillez M, Taque S, Harambat J, Michel-Bourdat G, Guigonis V, Fila M, Cloarec S, Djamal-Dine D, de Parscaux L, Allard L, Salomon R, Ulinski T, Frémeaux-Bacchi V, Morin C, Olivier-Abbal P, Colineaux H, Auriol F, Arnaud C, Kieffer I, Brusq C. Efficacy and Safety of Eculizumab in Pediatric Patients Affected by Shiga Toxin-Related Hemolytic and Uremic Syndrome: A Randomized, Placebo-Controlled Trial. J Am Soc Nephrol. 2023 Sep 1;34(9):1561-1573. doi: 10.1681/ASN.0000000000000182.
  1. Arnaud C. Describing functional skills in children with cerebral palsy close to age 5 years matters. Dev Med Child Neurol. 2022 Dec;64(12):1435-1436. doi: 10.1111/dmcn.15372.
  2. Delobel-Ayoub M, Ehlinger V, Klapouszczak D, Duffaut C, Arnaud C, Sentenac M. Prevalence and characteristics of children with cerebral palsy according to socioeconomic status of areas of residence in a French department. PLoS One. 2022 May 19;17(5):e0268108. doi: 10.1371/journal.pone.0268108.
  3. Groussolles M, Winer N, Sentilhes L, Biquart F, Massoud M, Vivanti AJ, Bouchghoul H, Rozenberg P, Olivier P, Desbriere R, Chauleur C, Perrotin F, Coatleven F, Fuchs F, Bretelle F, Tsatsaris V, Salomon LJ, Sananes N, Kayem G, Houflin-Debarge V, Schmitz T, Benoist G, Arnaud C, Ehlinger V, Vayssière C; Groupe de Recherche en Gynecologie Obstétrique (GROG). Arabin pessary to prevent adverse perinatal outcomes in twin pregnancies with a short cervix: a multicenter randomized controlled trial (PESSARONE). Am J Obstet Gynecol. 2022 Aug;227(2):271.e1-271.e13. doi: 10.1016/j.ajog.2022.01.038.
  4. Lorthe E, Letouzey M, Torchin H, Foix L'Helias L, Gras-Le Guen C, Benhammou V, Boileau P, Charlier C, Kayem G; EPIPAGE-2 Obstetric Writing Group (Arnaud C collaborator). Antibiotic prophylaxis in preterm premature rupture of membranes at 24-31 weeks' gestation: Perinatal and 2-year outcomes in the EPIPAGE-2 cohort. BJOG. 2022 Aug;129(9):1560-1573. doi: 10.1111/1471-0528.17081.
  5. McIntyre S, Goldsmith S, Webb A, Ehlinger V, Hollung SJ, McConnell K, Arnaud C, Smithers-Sheedy H, Oskoui M, Khandaker G, Himmelmann K; Global CP Prevalence Group*. Global prevalence of cerebral palsy: A systematic analysis. Dev Med Child Neurol. 2022 Dec;64(12):1494-1506. doi: 10.1111/dmcn.15346.
  6. Schmidt S, Markwart H, Rapp M, Guyard A, Arnaud C, Fauconnier J, Thyen U, Hahm S, Vidart d'Egurbide Bagazgoïtia N, Muehlan H. Quality of life and mental health in emerging adults with cerebral palsy compared to the general population. Health Qual Life Outcomes. 2022 Apr 2;20(1):61. doi: 10.1186/s12955-022-01961-7.
  1. Arnaud C, Duffaut C, Fauconnier J, Schmidt S, Himmelmann K, Marcelli M, Pennington L, Alvarelhão J, Cytera C, Rapp M, Ehlinger V, Thyen U. Determinants of participation and quality of life of young adults with cerebral palsy: longitudinal approach and comparison with the general population - SPARCLE 3 study protocol. BMC Neurol. 2021 Jun 30;21(1):254. doi: 10.1186/s12883-021-02263-z.
  2. Arnaud C, Ehlinger V, Delobel-Ayoub M, Klapouszczak D, Perra O, Hensey O, Neubauer D, Hollódy K, VirellaD, Rackauskaite G, Greitane A, Himmelmann K, Ortibus E, Dakovic I, Andersen GL, Papavasiliou A, Sellier E, Platt MJ, Krägeloh-Mann I. Trends in Prevalence and Severity of Pre/Perinatal Cerebral Palsy Among Children Born Preterm From 2004 to 2010: A SCPE Collaboration Study. Front. Neurol. 20 May 2021. doi.org/10.3389/fneur.2021.624884
  3. Breinig S, Dicky O, Ehlinger V, Dulac Y, Marcoux MO, Arnaud C. Echocardiographic Parameters Predictive of Poor Outcome in Persistent Pulmonary Hypertension of the Newborn (PPHN): Preliminary Results. Pediatr Cardiol. 2021 Dec;42(8):1848-1853. doi: 10.1007/s00246-021-02677-z.
  4. Breinig S, Mortamet G, Brossier D, Amadieu R, Claudet I, Javouhey E, Angoulvant F, Arnaud C. Impact of the French National Lockdown on Admissions to 14 Pediatric Intensive Care Units During the 2020 COVID-19 Pandemic-A Retrospective Multicenter Study. Front Pediatr. 2021 Dec 10;9:764583. doi: 10.3389/fped.2021.764583.
  5. Fernandez de Grado G, Ehlinger V, Godeau E, Arnaud C, Nabet C, Benkirane-Jessel N, Musset AM, Offner D. Changes in tooth brushing frequency and its associated factors from 2006 to 2014 among French adolescents: Results from three repeated cross sectional HBSC studies. PLoS One. 2021 Mar 29;16(3):e0249129. doi: 10.1371/journal.pone.0249129.
  6. Gaudineau A, Senat MV, Ehlinger V, Gallini A, Morin M, Olivier P, Roth E, Orusco E, Javoise S, Fort J, Lavergne C, Arnaud C, Rozenberg P, Vayssiere C; Groupe de Recherche en Obstétrique rt Gynécologie. Induction of labor at term with vaginal misoprostol or a prostaglandin E2 pessary: a noninferiority randomized controlled trial. Am J Obstet Gynecol. 2021 Apr 19:S0002-9378(21)00456-7. doi: 10.1016/j.ajog.2021.04.226.
  7. Gire C, Beltran Anzola A, Kaminski M, Baumstarck K, Ancel PY, Berbis J; for EPIREMED-Study Group (Arnaud C collaborator). A randomized EPIREMED protocol study on the long-term visuo spatial effects of very preterm children with a working memory deficit. BMC Pediatr. 2021 Sep 13;21(1):402. doi: 10.1186/s12887-021-02867-x. P
  8. Horber V, Grasshoff U, Sellier E, Arnaud C, Krägeloh-Mann I, Himmelmann K. The Role of Neuroimaging and Genetic Analysis in the Diagnosis of Children With Cerebral Palsy. Front Neurol. 2021 Feb 9;11:628075. doi: 10.3389/fneur.2020.628075.
  9. Lannes A, Bui E, Arnaud C, Raynaud JP, Revet A. Preventive interventions in offspring of parents with mental illness: a systematic review and meta-analysis of randomized controlled trials. Psychol Med. 2021 Aug 26:1-16. doi: 10.1017/S0033291721003366. Epub ahead of print.
  10. Lorthe E, Letouzey M, Torchin H, Foix L'Helias L, Gras-Le Guen C, Benhammou V, Boileau P, Charlier C, Kayem G; EPIPAGE-2 Obstetric Writing Group (Arnaud C collaborator). Antibiotic prophylaxis in preterm premature rupture of membranes at 24-31 weeks' gestation: Perinatal and 2-year outcomes in the EPIPAGE-2 cohort. BJOG. 2021 Dec 26. doi: 10.1111/1471-0528.17081. Epub ahead of print.
  11. Losbar JL, Montjaux N, Ehlinger V, Germany L, Arnaud C, Tscherning C. Early discharge and hospital-assisted home care is associated with better neurodevelopmental outcome in preterm infants. Early Hum Dev. 2021.Oct. vol.161. doi: org/10.1016/j.earlhumdev.2021.105451.
  12. Pacoricona Alfaro DL, Diene G, Pinto G, Salles JP, Gennero I, Faye S, Molinas C, Valette M, Arnaud C, Tauber M. Is ghrelin a biomarker of early-onset scoliosis in children with Prader-Willi syndrome? Orphanet J Rare Dis. 2021 Jul 8;16(1):305. doi: 10.1186/s13023-021-01930-1.
  13. Perra O, Rankin J, Platt MJ, Sellier E, Arnaud C, De La Cruz J, Krägeloh-Mann I, Sweet DG, Bjellmo S. Decreasing cerebral palsy prevalence in multiple births in the modern era: a population cohort study of European data. Arch Dis Child Fetal Neonatal Ed. 2021 Mar;106(2):125-130. doi: 10.1136/archdischild-2020-318950.
  14. Pierrat V, Marchand-Martin L, Marret S, Arnaud C, Benhammou V, Cambonie G, Debillon T, Dufourg MN, Gire C, Goffinet F, Kaminski M, Lapillonne A, Morgan AS, Rozé JC, Twilhaar S, Charles MA, Ancel PY; EPIPAGE-2 writing group. Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study. BMJ. 2021 Apr 28;373:n741. doi: 10.1136/bmj.n741.
  15. Sentenac M, Rapp M, Ehlinger V, Colver A, Thyen U, Arnaud C. Disparity of child/parent-reported quality of life in cerebral palsy persists into adolescence. Dev Med Child Neurol. 2021 Jan;63(1):68-74. doi: 10.1111/dmcn.14638.
  16. Tosello B, Garbi A, Blanc J, Lorthe E, Foix-L'Hélias L, D'Ercole C, Winer N, Subtil D, Goffinet F, Kayem G, Resseguier N, Gire C; EPIPAGE-2 Obstetric Writing Group (Arnaud C collaborator). The impact of chorionicity on pregnancy outcome and neurodevelopment at 2 years old among twins born preterm: the EPIPAGE-2 cohort study. BJOG. 2021 Jan;128(2):281-291. doi: 10.1111/1471-0528.16170.
  17. Vidart d'Egurbide Bagazgoïtia N, Ehlinger V, Duffaut C, Fauconnier J, Schmidt-Schuchert3, Thyen U, Himmelmann K, Marcelli M, Arnaud C. Quality of Life in Young Adults With Cerebral Palsy: A Longitudinal Analysis of the SPARCLE Study. Front. Neurol., 01 November 2021. doi.org/10.3389/fneur.2021.733978.
  18. Vaivre-Douret L, Mazeau M, Jolly C, Huron C, Arnaud C, Gonzalez-Monge S, Assaiante C. L'expertise collective de l'Inserm sur le trouble développemental de la coordination ou dyspraxie : état des principaux travaux et recommandations. Neurpsychiatrie de l'enfance et de l'adolescence. 2021. 69(6):311-330. doi :  10.1016/j.neurenf.2021.07.002.
  1. Delobel-Ayoub M, Saemundsen E, Gissler M, Ego A., Moilanen I, Ebeling H, Rafnsson V, Klapouszczak D, Thorsteinsson E, Arnaldsdóttir KM, Roge B, Arnaud C, Schendel D. Prevalence of Autism Spectrum Disorder in 7-9-Year-Old Children in Denmark, Finland, France and Iceland: A Population-Based Registries Approach Within the ASDEU Project. J Autism Dev Disord. 2020;50(3):949–959. doi: 10.1007/s10803-019-04328-y.
  2. Delorme P, Kayem G, Lorthe E, Sentilhes L, Zeitlin J, Subtil D, Rozé JC, Vayssière C, Durox M, Ancel PY, Pierrat V, Goffinet F; EPIPAGE-2 Obstetric Writing Group (Arnaud C collaborator). Neurodevelopment at 2 years and umbilical artery Doppler in cases of very preterm birth after prenatal hypertensive disorder or suspected fetal growth restriction: EPIPAGE-2 prospective population-based cohort study. Ultrasound Obstet Gynecol. 2020 Oct;56(4):557-565. doi: 10.1002/uog.22025.
  3. Himmelmann K, Påhlman M, Andersen GL, Vik T, Virella D, Horridge K, Neubauer D, Arnaud C, Rackauskaite G, de la Cruz J. Access to Intrathecal Baclofen Treatment for Children with Cerebral Palsy in European Countries: An SCPE Survey Reveals Important Differences. Neuropediatrics. 2020;51(2):129‐134. doi: 10.1055/s-0040-1701659.
  4. Horber V, Fares A, Platt MJ, Arnaud C, Krägeloh-Mann I, Sellier E. Severity of Cerebral Palsy-The Impact of Associated Impairments. Neuropediatrics. 2020;51(2):120‐128. doi: 10.1055/s-0040-1701669.
  5. Horber V, Sellier E, Horridge K, , Rackauskaite G, Andersen GL, Virella D, Ortibus E, Dakovic I, Hensey O, Radsel A, Papavasiliou A, Cruz De la J, Arnaud C, Krägeloh-Mann I, Himmelmann K. The Origin of the Cerebral Palsies: Contribution of Population-Based Neuroimaging Data. Neuropediatrics. 2020;51(2):113‐119. doi: 10.1055/s-0039-3402007.
  6. Maisonneuve E, Lorthe E, Torchin H, Delorme P, Devisme L, L'Hélias LF, Marret S, Subtil D, Bodeau-Livinec F, Pierrat V, Sentilhes L, Goffinet F, Ancel PY, Kayem G; EPIPAGE-2 Obstetric writing group Group (Arnaud C collaborator). Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study. J Pediatr. 2020 Jul;222:71-78.e6. doi: 10.1016/j.jpeds.2020.03.021.
  7. Pierrat V, Burguet A, Marchand-Martin L, Cambonie G, Coquelin A, Roze JC, Durox M, Guillois B, Morgan AS, Kaminski M; Neurodevelopmental care study group of EPIPAGE-2 (Arnaud C collaborator). Variations in patterns of care across neonatal units and their associations with outcomes in very preterm infants: the French EPIPAGE-2 cohort study. BMJ Open. 2020 Jun 22;10(6):e035075. doi10.1136/bmjopen-2019-035075.
  8. Pierrat V, Marchand-Martin L, Durrmeyer X, Vasante L, Burguet A, Cambonie G, Kuhn P, Datin-Dorrière V, Durox M, Kaminski M, Carbajal R, Ancel PY; Neurodevelopmental Care Study Group of EPIPAGE -2. (Arnaud C collaborator). Perceived maternal information on premature infant's pain during hospitalization: the French EPIPAGE-2 national cohort study. Pediatr Res. 2020. 87 (1), 153-162. doi10.1038/s41390-019-0422-8.
  9. Saurel-Cubizolles MJ, Marchand-Martin L, Pierrat V, Arnaud C, Burguet A, Fresson J, Marret S, Roze JC, Cambonie G, Matis J, Kaminski M, Ancel PY. Maternal employment and socio-economic status of families raising children born very preterm with motor or cognitive impairments: the EPIPAGE cohort study [published online ahead of print, 2020 Jun 18]. Dev Med Child Neurol. 2020;10.1111/dmcn.14587. doi: 10.1111/dmcn.14587.
  • Drummond D, Hadchouel A, Torchin H, Rozé JC, Arnaud C, Bellino A, Couderc L, Marret S, Mittaine M, Pinquier D, Vestraete M, Rousseau J, Ancel PY, Delacourt C; EPIPAGEADO study group. Educational and health outcomes associated with bronchopulmonary dysplasia in 15-year-olds born preterm. PLoS One. 2019 Sep 11;14(9):e0222286. doi: 10.1371/journal.pone.0222286.
  • Lorthe E, Sentilhes L, Quere M, Lebeaux C, Winer N, Torchin H, Goffinet F, Delorme P, Kayem G; EPIPAGE-2 Obstetric Writing Group (Arnaud C collaborator). Planned delivery route of preterm breech singletons, and neonatal and 2-year outcomes: a population-based cohort study. BJOG. 2019 Jan;126(1):73-8 doi: 10.1111/1471-0528.15466.
  • Pacoricona Alfaro DL, Lemoine P, Ehlinger V, Molinas C, Diene G, Valette M, Pinto G, Coupaye M, Poitou-Bernert C, Thuilleaux D, Arnaud C, Tauber M. Causes of death in Prader-Willi syndrome: lessons from 11 years' experience of a national reference center. Orphanet J Rare Dis. 2019 Nov 4;14(1):238. doi10.1186/s13023-019-1214-2.